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MICROBIAL COMMUNITIES AND INTERACTIONS

Identification and Characterization of OscR, a Transcriptional Regulator Involved in Osmolarity Adaptation in Vibrio cholerae

Nicholas J. Shikuma, Fitnat H. Yildiz
Nicholas J. Shikuma
Department of Microbiology and Environmental Toxicology, University of California, Santa Cruz, Santa Cruz, California 95064
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Fitnat H. Yildiz
Department of Microbiology and Environmental Toxicology, University of California, Santa Cruz, Santa Cruz, California 95064
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  • For correspondence: yildiz@metx.ucsc.edu
DOI: 10.1128/JB.01540-08
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ABSTRACT

Vibrio cholerae is a facultative human pathogen. In its aquatic habitat and as it passes through the digestive tract, V. cholerae must cope with fluctuations in salinity. We analyzed the genome-wide transcriptional profile of V. cholerae grown at different NaCl concentrations and determined that the expression of compatible solute biosynthesis and transporter genes, virulence genes, and genes involved in adhesion and biofilm formation is differentially regulated. We determined that salinity modulates biofilm formation, and this response was mediated through the transcriptional regulators VpsR and VpsT. Additionally, a transcriptional regulator controlling an osmolarity adaptation response was identified. This regulator, OscR (osmolarity controlled regulator), was found to modulate the transcription of genes involved in biofilm matrix production and motility in a salinity-dependent manner. oscR mutants were less motile and exhibited enhanced biofilm formation only under low-salt conditions.

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Identification and Characterization of OscR, a Transcriptional Regulator Involved in Osmolarity Adaptation in Vibrio cholerae
Nicholas J. Shikuma, Fitnat H. Yildiz
Journal of Bacteriology Jun 2009, 191 (13) 4082-4096; DOI: 10.1128/JB.01540-08

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Identification and Characterization of OscR, a Transcriptional Regulator Involved in Osmolarity Adaptation in Vibrio cholerae
Nicholas J. Shikuma, Fitnat H. Yildiz
Journal of Bacteriology Jun 2009, 191 (13) 4082-4096; DOI: 10.1128/JB.01540-08
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KEYWORDS

Bacterial Proteins
Gene Expression Regulation, Bacterial
Osmolar Concentration
Transcription, Genetic
Vibrio cholerae

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