Cover photograph (Copyright © 2014, American Society for Microbiology. All Rights Reserved.): Colonies of a Pseudomonas aeruginosa clinical strain isolated from the airways of a patient with the genetic disease cystic fibrosis. The colonies grown on agar are iridescent and show autolysis. Such phenotypes are observed in Pseudomonas aeruginosa laboratory mutant strains (such as the ΔrelA ΔspoT mutant described by Schafhauser et al. in this issue) and clinical isolates that accumulate excessive 4-hydroxy-2-alkylquinoline (HAQ) molecules. (See related article on page 1641.)