Transcriptional Regulation by the Short-Chain Fatty Acyl Coenzyme A Regulator (ScfR) PccR Controls Propionyl Coenzyme A Assimilation by Rhodobacter sphaeroides

Neighbor-joining tree of selected ScfR proteins. Nodes with bootstrap values greater than 50% are labeled. Each entry includes the class name assigned to the given protein on the basis of the genomic context of its respective gene. A question mark indicates that the corresponding genetic context does not contain any genes of the indicated metabolic gene clusters. An asterisk indicates a protein that clusters in the tree with proteins of a different class. Following the protein name is the locus tag for the given protein and the species in which the protein is found. To the right of the tree is an illustration of the general genome neighborhood of the genes that encode proteins from the corresponding clade. See Fig. S2 in the supplemental material for the extended tree. A DNA logo (50) is included if a conserved motif was identified upstream of the genes responsible for the proteins in the corresponding clade. The indicated motifs may have occurred multiple times in the queried sequences. Gene annotations are as follows: pccB, propionyl-CoA carboxylase β subunit; pccA, propionyl-CoA carboxylase α subunit; mcm, methylmalonyl-CoA mutase; prpB, 2-methylcitrate lyase; prpC, 2-methylcitrate synthase; prpD, 2-methylcitrate dehydratase; prpE, propionyl-CoA synthetase; mmsA, methylmalonate semialdehyde dehydrogenase; hibA, acyl-CoA dehydrogenase; hibB, enoyl-CoA hydratase; mmsB, 3-hydroxyisobutyrate dehydrogenase; aceA, isocitrate dehydrogenase; aceB, malate synthase.