DOI: 10.1128/JB.00200-11
ABSTRACT
Many enteric bacteria use bile as an environmental cue to signal resistance and virulence gene expression. Microarray analysis of enterohemorrhagic Escherichia coli O157:H7 (EHEC) treated with bile salts revealed up-regulation of genes for an efflux system (acrAB), a two-component signal transduction system (basRS/pmrAB) and lipid A modification (arnBCADTEF and ugd). Bile salt treatment of EHEC produced a basS- and arnT-dependent resistance to polymyxin.
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