PT  - JOURNAL ARTICLE
AU  - Tuckman, M
AU  - Osburne, M S
TI  - In vivo inhibition of TonB-dependent processes by a TonB box consensus pentapeptide.
AID  - 10.1128/jb.174.1.320-323.1992
DP  - 1992 Jan 01
TA  - Journal of Bacteriology
PG  - 320--323
VI  - 174
IP  - 1
4099  - http://jb.asm.org/content/174/1/320.short
4100  - http://jb.asm.org/content/174/1/320.full
SO  - J. Bacteriol.1992 Jan 01; 174
AB  - The TonB box, a conserved pentapeptide sequence found in TonB-dependent colicins and receptors, is thought to interact physically with the TonB protein to facilitate TonB-dependent processes. Strains of Escherichia coli were treated in vivo with the synthetic TonB box pentapeptide Glu-Thr-Val-Ile-Val. The pentapeptide inhibited several TonB-dependent processes, including cell growth in low-iron medium, phi 80 infection, and killing by colicins B and Ia. Two unrelated control pentapeptides had no effect on TonB-dependent processes.