RT Journal Article
SR Electronic
T1 Biochemical Bases for the Antimetabolite Action of <span class="sc">l</span>-Serine Hydroxamate
JF Journal of Bacteriology
JO J. Bacteriol.
FD American Society for Microbiology
SP 972
OP 982
VO 106
IS 3
A1 Tosa, Tetsuya
A1 Pizer, Lewis I.
YR 1971
UL http://jb.asm.org/content/106/3/972.abstract
AB The amino acid analogue l-serine hydroxamate, which is bacteriostatic for Escherichia coli, has been shown to inhibit protein synthesis. The antimetabolite is a competitive inhibitor of seryl-transfer ribonucleic acid (tRNA) synthetase with a Ki value of 30 μm. Mutants resistant to l-serine hydroxamate have been selected, and three were shown to have seryl-tRNA synthetases with increased Ki values. One mutant contains a 3-phosphoglycerate dehydrogenase which is insensitive to inhibition by l-serine.