RT Journal Article
SR Electronic
T1 A Typhus Group-Specific Protease Defies Reductive Evolution in Rickettsiae
JF Journal of Bacteriology
JO J. Bacteriol.
FD American Society for Microbiology
SP 7609
OP 7613
DO 10.1128/JB.01077-09
VO 191
IS 24
A1 Ammerman, Nicole C.
A1 Gillespie, Joseph J.
A1 Neuwald, Andrew F.
A1 Sobral, Bruno W.
A1 Azad, Abdu F.
YR 2009
UL http://jb.asm.org/content/191/24/7609.abstract
AB Phylogenomics reveals extreme gene loss in typhus group (TG) rickettsiae relative to the levels for other rickettsial lineages. We report here a curious protease-encoding gene (ppcE) that is conserved only in TG rickettsiae. As a possible determinant of host pathogenicity, ppcE warrants consideration in the development of therapeutics against epidemic and murine typhus.