Y. pestis phoP G215 mutant strain is more susceptible to antimicrobial peptide polymyxin Ba

StrainPolymyxin B MIC (μM) at:
KIM6+ WT7.8131.250.49
KIM6+ ΔphoP0.490.98ND
KIM6+ phoP-G2150.983.910.49
  • a Bacteria were grown for 20 h in low-Mg2+ TMH medium containing various concentrations of polymyxin B (0.12 to 125 μM) at the indicated temperatures, and the MICs were determined as the lowest concentration at which no bacterial growth was seen. At least three independent experiments were performed, and the results of one representative experiment are shown.