Table 1.

Lipoheptapeptide antibiotics of Bacillus spp.

LipopeptideOrganismStructureReference
Lichenysin A B. licheniformis FA a -L-Glu-L-Leu-D-Leu-L-Val-L-Asn-D-Leu-L-Ile 51,52
Lichenysin B FA a -L-Glu-L-Leu-D-Leu-L-Val-L-Asp-D-Leu-L-Leu 23,26
Lichenysin C FA a -L-Glu-L-Leu-D-Leu-L-Val-L-Asp-D-Leu-L-Ile 17
Lichenysin D FA a -L-Gln-L-Leu-D-Leu-L-Val-L-Asp-D-Leu-L-Ile This work
Surfactant 86 B. licheniformis FA a -L-Glx d -L-Leu-D-Leu-L-Val-L-Asx d -D-Leu-L-Ile e 14,15
L-Val
Surfactin B. subtilis FA a -L-Glu-L-Leu-D-Leu-L-Val-L-Asp-D-Leu-L-Leu 1,7, 49
Esperin B. subtilis FA b -L-Glu-L-Leu-D-Leu-L-Val-L-Asp-D-Leu-L-Leu e 45
L-Val 
Iturin A B. subtilis FA c -L-Asn-D-Tyr-D-Asn-L-Gln-L-Pro-D-Asn-L-Ser 32
Iturin C FA c -L-Asn-D-Tyr-D-Asn-L-Gln-L-Pro-D-Asn e -L-Asn e 34
D-Ser-L-Thr 
Bacillomycin L B. subtilis FA c -L-Asp-D-Tyr-D-Asn-L-Ser-L-Gln-D-Pro e -L-Thr 3
D-Ser- 
Bacillomycin D FA c -L-Asp-D-Tyr-D-Asn-L-Pro-L-Glu-D-Ser-L-Thr 30,31
Bacillomycin F FA c -L-Asn-D-Tyr-D-Asn-L-Gln-L-Pro-D-Asn-L-Thr 27
  • a FA, β-hydroxy fatty acid. The β-hydroxy group forms an ester bond with the carboxy group of the C-terminal amino acid.

  • b FA, β-hydroxy fatty acid. The β-hydroxy group forms an ester bond with the carboxy group of Asp5.

  • c FA, β-amino fatty acid. The β-amino group forms a peptide bond with the carboxy group of the C-terminal amino acid.

  • d Only the following combinations of amino acid 1 and 5 are allowed: Gln-Asp or Glu-Asn.

  • e Where an alternative amino acid may be present in a structure, the alternative is also presented.