Table 2.

Environmental and genetic regulation of S. typhimurium ivi genes

StrainGeneFunctionEnvironmental signal(s)PhoPQ regulationParametersReference(s)a
MT1371 phoP Virulence regulatorpH + Mg2+ pag i.g., i.p./spleenb 16,23, 38, 40, this work
MT1698 pmrB Polymyxin resistancepH + Mg2+ pag Cultured macrophage 21, 23, 39, this work
MT1701 spvB Plasmid virulencepH + Mg2+ pag i.p./spleen 13,23, this work
MT1228 mgtA Mg2+transportpH + Mg2+ pag i.p./spleen; cultured macrophage 16, 23, 39, 40, this work
MT1695 mgtB Mg2+transportpH + Mg2+ pag i.p./spleen 15,16, 23, 40, 41, this work
MT1704 iviVI-A Adhesin-likepH + Mg2+ pag i.p./spleen 23, this work
MT1818 iviXVI Aldehyde dehydrogenase-likepH + Mg2+ pag i.p./spleenThis work
MT1819 iviXVII (pdu)1,2-Propanediol utilizationpH + Mg2+, iron O2, propanediol prg i.p./spleen 1, 5, this work
MT1772 fhuA Iron transportIron None i.g./small intestine 23, 41, this work
MT1833 cirA Colicin 1 receptorIron None Cultured macrophage 23, this work
MT1801 entF Enterobactin synthesisIron None Cultured macrophage 23, this work
  • a Listed are references relevant to environmental signals that affect ivi gene expression inS. typhimurium.

  • b Route of delivery (intragastric [i.g.] or intraperitoneal [i.p.])/host tissue from which bacteria were recovered.