Table 2.

Strain classification by hif genotype and hemagglutination phenotype

StrainaSourcebClasschifAd hicABe HAf
Hib EaganCSF, meningitis patientIV+, (AT)10 +
RdLI
Type aLV++
Type bLV++
Type cLVII++
Type dLI
Type eLI
Type fLIIIb−, (AT)5 ±
INT1Blood, meningitis patientVI+, (AT)4 +
R2777CSFI
R3001Bronchial infectionIIa+
R1965LIIa+
U11CSFIIa+
C2836Otitis mediaIIa+
C2840Tracheal infectionIIb+±
Hib C2843Otitis mediaV+
C2853SputumIIa+
C2859CSFIIb+
C2861CSFIIIa−, (AT)4 +±
Hib AM30g CSF, meningitis patientV+, (AT)10 +
  • a Types a to f are the reference strains for each capsular serotype. All other isolates except those designated Hib are nontypeable.

  • b L, laboratory reference strain.

  • c hif genotype classification (Fig.6).

  • d Presence (+) or absence (−) of an intacthifA gene and number of AT repeats in the hifApromoter, if known. For strains showing phase variation, the number of repeats is that in a piliated variant; for INT1, C2861, and type f, the number of repeats is that in the original isolate.

  • e Presence (+) or absence (−) of intact copies of both hicA and hicB within the region betweenpurE and pepN.

  • f HA, hemadsorption ability after enrichment for adherent variants (see Materials and Methods). +, macroagglutination; ±, microagglutination (see Materials and Methods).

  • g Data are from references43 and 44.