Table 3.

Virulence in a systemic mouse model of experimental infection in BALB/c and DBA/2 mice

Challenge doseStrainTimeaFungal burden (log CFU)b in:
BALB/c miceDBA/2 mice
KidneyBrainKidneyBrain
1 × 107 SC531416.03 ± 0.844.47 ± 0.13NTc NT
CNC1314.39 ± 0.243.24 ± 0.25.27 ± 0.213.98 ± 0.13
1 × 106 SC531415.93 ± 0.184.04 ± 0.226.02 ± 0.923.81 ± 0.16
CNC1313.26 ± 0.241.89 ± 0.31* 4.43 ± 0.093.16 ± 0.13
73.94 ± 1.13 *
605.11 ± 0.98** *
1 × 105 SC531413.61 ± 0.103.34 ± 0.365.17 ± 0.763.70 ± 0.19
74.10 ± 0.84 *
604.32 ± 1.51* *
CNC1312.53 ± 0.211.78 ± 0.00** 3.76 ± 0.082.35 ± 0.18
7 * * 3.60 ± 0.98* 3.34 ± 0.00**
604.98 ± 0.00*** * 4.35 ± 0.35** *
5 × 104 SC531476.45 ± 0.564.53 ± 0.50
604.87 ± 0.96* *
CNC131 * * 3.71 ± 0.733.66 ± 0.00**
7 * * * *
60 * * 3.92 ± 0.00** *
  • a Day postchallenge (up to MST) when mice were killed by cervical dislocation for CFU quantification.

  • b Only log CFU values that are statistically significantly different at P = 0.003 (kidney) and P < 0.0001 (brain) are shown (analysis of variance test with C. albicans strain; covariates were time, mice, and dose). *, some or all mice cleared infection; **, more than 50% mice cleared infection.

  • c NT, not tested.