Table 4.

Effect of rpoS mutation on chronic lung infection caused by P. aeruginosa

Parent or mutantInitial inoculum (CFU/ml)Quantitative bacteriology (CFU/ml) on daya:Quantitative pathology (% damage) on day:
7147b14
RpoS+(PAO1)3.5 × 104 (4.4 ± 4.3) × 105 (1.3 ± 1.2) × 105 18.5 ± 4.920.9 ± 8.8
RpoS(SS24)2.8 × 104 (2.3 ± 2.2) × 106 1.2 × 106 ± 9.2 × 105 32.7 ± 3.8c 56.2 ± 19.3c
  • a Values are means ± standard deviations.

  • b Infiltration index.

  • c Significantly different from RpoS+ value (P < 0.05) by Student’s t test.