Table 2.

Adherence of wild-type and isogenic mutant strains ofM. catarrhalis to Chang conjunctival epithelial cells in vitro

StrainGenotypeAdherencea
012EWild type123.0 ± 15.57
012E.1 uspA1 mutant9.3 ± 3.8 (0.0001)
012E.2 uspA2 mutant138.3 ± 19.6 (0.0088)
012E.12 uspA1 uspA2 mutant14.1 ± 3.8 (0.0001)
TTA37Wild type42.4 ± 17.3
TTA37.1 uspA1 mutant45.8 ± 14.7 (0.6593)
TTA37.2 uspA2H mutant6.7 ± 2.1 (0.0003)
TTA37.12 uspA1 uspA2Hmutant4.5 ± 0.5 (0.0002)
046EWild type52.1 ± 13.1
046E.1 uspA1mutant55.2 ± 14.3 (0.6725)
046E.2 uspA2Hmutant45.4 ± 18.1 (0.4847)
046E.12 uspA1 uspA2H mutant6.7 ± 2.2 (0.0001)
  • a Adherence of M. catarrhalisto Chang cells is expressed as the mean (± standard deviation) percentage of the inoculum which adhered to the monolayers. TheP value compared to the value for the wild-type parent strain, using a two-tailed t test, is given in parentheses.