Table 1.

Windows opened by viruses: phages M13 and φX174

Provided the DNA substrates that enabled the discovery of RNA priming as a general mechanism for starting a DNA chain
Discovery of the single-strand binding protein needed to identify the origin for priming and to facilitate processive replication
Discovery of the highly mobile primosome
Recognition of a far more complex DNA polymerase, the pol III holoenzyme, a dimeric, 20-subunit, highly processive component of the replisome
Discovery of a helicase that operates at a replication fork