Table 1.

Genes affected by constitutive expression of MarA

Gene nameProductaFold changeb
Increased expression
acnAAconitate hydrase 12.7/5.9
 acrAAcridine efflux pump1.9/2.3
 aldAAldehyde dehydrogenase, NAD linked7.4/3.2
 b0447Putative LRP-like transcriptional regulator3.5/4.4
 b0853Putative sensory transduction regulator1.4/4.2
 b1448Putative resistance protein1.8/2.3
 b2889Putative enzyme2.5/5.6
 b2948ORF; hypothetical protein1.4/2.5
 cobUCobinamide kinase or cobinamide phosphate guanylyltransferase1.6/2.2
 fumCFumarase C (fumarase hydratase class II); isoenzyme2.5/2.9
 galKGalactokinase1.5/2.0
 galTGalactose-1-phosphate uridylyltransferase2.5/2.4
 gatAGalactitol-specific enzyme IIA of phosphotransferase system2.0/1.8
 gatCPTS system galactitol-specific enzyme IIC3.4/1.6
 gltACitrate synthase2.1/1.9
 gshBGlutathione synthetase3.5/5.7
 hemB5-Aminolevulinate dehydratase5.7/5.1
 inaApH-inducible protein involved in stress response5.0/20.2
 mapMethionine aminopeptidase1.7/2.1
 marAMultiple-antibiotic resistance; activator24.0/46.6
 marBMultiple-antibiotic resistance protein7.5/16.3
 marRMultiple-antibiotic resistance protein; repressor15.9/46.3
 mdaAModulator of drug activity A3.8/8.2
 mdaBModulator of drug activity B5.5/8.2
 mglBGalactose-binding transport protein; receptor for galactose taxis5.3/2.6
 mtrTryptophan-specific transport protein1.3/2.2
 nfnBOxygen-insensitive NADPH nitroreductase12.4/20.1
 ompXOuter membrane protein X1.6/2.1
 pflBFormate acetyltransferase 12.1/2.2
 pgiGlucose-6-phosphate isomerase2.4/2.1
 ribAGTP cyclohydrolase II1.1/2.2
 ribDBifunctional pyrimidine deaminase or reductase in pathway of riboflavin synthesis1.7/2.5
 rimKRibosomal protein S6 modification protein1.6/3.0
 sodASuperoxide dismutase, manganese7.0/4.6
 srlA2PTS system, glucitol/sorbitol-specific IIB component and second of two IIC component3.0/2.0
 tnaATryptophanase7.9/8.4
 tnaLTryptophanase leader peptide1.3/2.1
 tolCOuter membrane channel; specific tolerance to colicin E1; segregation of daughter chromosomes3.1/2.8
 tpxThiol peroxidase2.1/1.6
 yadGPutative ATP-binding component of a transport system9.2/11.2
 yadHORF; hypothetical protein1.9/2.7
 ybjCORF; hypothetical protein6.7/17.4
 ydeAPutative resistance or regulatory protein1.9/3.9
 yfaEORF; hypothetical protein2.5/5.9
 yggJORF; hypothetical protein3.1/4.2
 yhbWPutative enzyme10.6/6.5
 zwfGlucose-6-phosphate dehydrogenase2.7/1.8
Decreased expression
 accBAcetyl coenzyme A carboxylase, BCCP subunit; carrier of biotin2.2/2.0
 aceEPyruvate dehydrogenase (decarboxylase component)6.1/5.2
 aceFPyruvate dehydrogenase (dihydrolipoyltransacetylase component)5.1/4.1
 ackAAcetate kinase1.8/2.6
 b0357Putative alpha helix chain3.2/2.2
 b2530Putative aminotransferase1.2/2.3
 b3469Zinc-transporting ATPase1.6/2.2
 fabB3-Oxoacyl-(acyl carrier protein) synthase I2.6/3.1
 fecAOuter membrane receptor, citrate-dependent iron transport2.5/2.8
 glpDSn-glycerol-3-phosphate dehydrogenase (aerobic)1.4/2.1
 guaBIMP dehydrogenase2.9/2.3
 ndhRespiratory NADH dehydrogenase5.8/3.8
 ompFOuter membrane protein 1a (Ia, b, F)2.7/3.0
 purAAdenylosuccinate synthetase2.1/2.1
 rplE50S ribosomal subunit protein L53.5/2.0
  • a From the E. coli K-12 genome project (http://www.genetics.wisc.edu/ ). PTS, phosphotransferase system.

  • b Fold changes in gene expression between experimental and control samples obtained from two independent experiments.