Table 1.

Properties of m eAda-inducible promoters

PromoterLocation of the Ada binding siteTarget subunit in RNA polymeraseEffect of meAda on transcription by EςSActivating region in AdaRegulation by unmethylated Ada
ada −57 to −45ς70 (negatively charged patch)ActivationCTDRepression
aidB −55 to −43ς70 (negatively charged patch)Activation (promoter is dependent on EςS for optimal expression)CTD???
alkA −47 to −35ς70 (positively charged patch) and αCTDRepressionNTDActivation