Table 2.

Characteristics of the HIV protease variants

Modified proteaseMutation(s)Phenotypic resistancea
SaquinavirIndinavir
B1V77I11
B3M46I, V77I, V82T313
V1L63P11
V2L10I, L63P, L90M534
  • a Fold increase in the concentration of inhibitors required for 50% inhibition of the viral replication in recombinant-virus assays (15), compared to wild-type HIV. These data were kindly provided by F. Clavel.