Table 1.

Comparison of heavy metal-associated motifsa of P-type heavy metal efflux ATPases

ATPaseResistance to:Heavy metal binding motifb
PbrA of R. metalliduransCH34Pb(II) IENMDCPTEEALIRDKLAKLPGV
IHQMDCPTEEALIRSKLAGIPGV
CadA of S. aureus Cd, Pb(II) VQGFTCANCAGKFEKNVKKIPGV
ZntA of E. coli Zn, Cd, Pb(II) VSGMDCAACARKVENAVRQLAGV
  • a The motifs of CadA (23,26) and ZntA (3, 26) have been identified by sequence comparison.

  • b Conserved amino acids are indicated in bold.