Table 1.

Genes found in R6-encoded proteins that have been studied for a role in S. pneumoniae virulence or as protective antigens to S. pneumoniaea

Gene no.Gene nameDescription
spr0121 pspA Surface protein (choline binding), functions in inhibition of complement activation and may involve lactoferrin binding (30, 48)
spr0286 hysA Hyaluronidase (30)
spr0674 sodA Manganese cofactored superoxide dismutase (30)
spr0867 lytB Endo-beta-N-acetylglucosaminidase (15)
spr0884 ppmA Surface-located proteinase maturation protein (33)
spr1042 iga Immunoglobulin A1 protease (49)
spr1323 nox (nadH) NADH oxidase (1)
spr1492, spr1493 psaB, psaC WithpsaA, part of manganese ABC transporter operon (30)
spr1494 psaA Adhesin, manganese ABC transporter substrate-binding protein (30)
spr1536, spr1531 nanA, nanB Neuraminidase, sialidase (30)
spr1707 amiA Oligopeptide ABC transporter substrate-binding protein (33)
spr1739 ply (tacY) Pneumolysin (thiol-activated cytolysin) (30)
spr1754 lytA Autolysin (N-acetylmuramoyl-l-alanine amidase) (30)
spr1995 cbpA (pcpA) Surface protein (choline binding), functions in adherence and immunoglobulin A inactivation (30)
spr0040b thmA Bacteriocin-like amphipathic pore-forming peptide precursor (26)
spr0059b bgaC Beta-galactosidase 3 (52)
spr0351,bspr0337b pcpC, cbpF (pcpC1) Surface protein (choline binding), unknown function
spr0462b blpS (iR1) Regulator of bacteriocin production (39)
spr0465b iP Bacteriocin-like peptide, regulator (39)
  • a Other genes with a role in virulence or pathogenesis include two-component regulator systems (13 paired histidine-kinase and response regulators, one orphan response regulator) (46); genes for peptidoglycan biosynthesis; genes for synthesis of teichoic acid; and genes for choline synthesis, export, and attachment (pkc, choline kinase; proWX andproV, choline transport; licD1 andlicD2, choline metabolism).

  • b Published gene(s) for which function or motif suggests roles in pathogenesis but which lack experimental verification.