TABLE 2.

Induction of transcripts attributed to response regulator gene amplification, as determined by amplification of cDNA samples

GeneaInduction (fold)b by:
baeRcpxRevgAompRrcsB
acrD154.11.7102.0
acrE0.31.40.53.30.6
bcr1.31.64.14.32.9
cusB0.41.10.73.31.3
emrA1.02.52.06.52.5
emrD0.70.91.12.61.5
emrE0.51.11.16.71.0
emrK0.41.67.62.51.2
fsr0.31.01.32.50.8
mdfA0.92.01.43.12.5
macA0.72.42.03.14.6
yceE0.32.10.93.30.9
yceL0.31.40.51.50.5
ydgF0.71.43.31.02.2
ydhE1.11.21.33.21.3
mdtA5303.42.51.43.3
yhiU0.20.8601.50.9
yidY0.21.50.53.00.5
yjiO0.21.30.32.40.7
acrA0.40.80.40.60.3
acrB0.50.70.50.50.2
  • a The amounts of mRNAs were measured in KAM3 cells as the host, except for acrA and acrB mRNAs, which were measured in TG1 cells. Five regulator genes which up-regulated drug transporter genes at least fourfold are shown.

  • b Values correspond to 2ΔCt, as described in Materials and Methods.