TABLE 4.

Drug resistance of E. coli cells harboring pTrc plasmids carrying baeR, cpxR, or ompR

StrainGenotypeOverexpressed regulatorMIC (μg/ml)a
acrDmdtABCDeoxycholateSDSNovobiocinKanamycin
KAM3++1,250500.783.13
KAM3ΔacrD+1,250500.783.13
KAM3ΔmdtABC+5,0001000.783.13
KAM3ΔacrDΔmdtABC1,250500.393.13
KAM3/baeR++BaeR>40,000200253.13
KAM3ΔacrD/baeR+BaeR>40,000200253.13
KAM3ΔmdtABC/baeR+BaeR>40,0002006.253.13
KAM3ΔacrDΔmdtABC/baeRBaeR1,250500.393.13
KAM3/cpxR++CpxR>40,000503.1312.5
KAM3ΔacrD/cpxR+CpxR1,250503.1312.5
KAM3/ompR++OmpR40,0001000.783.13
KAM3ΔacrD/ompR+OmpR40,0001000.783.13
  • a Values in boldface are larger than the control strain values.