TABLE 5.

Influence of σB on virulence determinants regulated by the agr locus

Virulence determinantGeneaResult forb:
agrσB
Aureolysinaur+
Capsular polysaccharide synthesis enzyme 5Jcap5J++
Clumping factor BclfB+
Coagulasecoa+
Cystein proteasesspC+
Enterotoxin Asea+Unknown
Enterotoxin Bseb+c
Exotoxin 2set8+Unknown
Factor effecting methicillin resistance BfemB+
Fibronectin-binding protein AfnbA+
Fibronectin-binding protein BfnbB
Glycerol ester hydrolyasegeh+
α-Hemolysinhla+
β-Hemolysinhlb+c
γ-HemolysinhlgBC+
δ-Hemolysinhld+
Hyaluronate lyasehysA+
Lipaselip+
LrgAB (holin-like proteins)lrgAB+
Myosin-cross-reactive antigenN315-SA0102+
Phosphatidylinositol-specific phospolipase Cplc+
Protein Aspa
Secretory antigen AssaA+
Serine protease A, B, D, and FsplA,B,D,F+
Staphylokinasespc+
Toxic shock syndrome toxin 1tst+Unknown
V8 proteasesspA+
  • a Genes that are regulated conversely by agr and σB are shown in boldface type.

  • b Influence of agr and σB on transcription of the respective gene. ∅, not influenced; +, increased; −, decreased.

  • c Based on transcript levels detected in strains COL and IK183.