TABLE 4.

Virulence attenuation of selected SMIT mutants

StrainDisrupted gene or homologSpleenaAbscessb
IVT24saeS−1.26−1.40
IVT59arlS−1.63−1.95
IVT133yflS−1.49−0.29
IVT176yuiF−3.09−2.59
IVT626aspB−2.47−3.28
IVT627pycA−1.65−3.60
IVT631gabP−2.82−3.14
IVT636pyrC−0.47−0.20
  • a Mean log10 CFU per gram of tissue difference relative to isogenic WT control in disseminated systemic infection of the spleen.

  • b Mean log10 CFU per gram of tissue difference relative to isogenic WT control in abscess infection.