TABLE 4.

Surface proteins in S. aureus and S. epidermidis

LocusFunctionaFunctional nameGene(s)SDb presentLPXTGcYSIRKd present
S. aureus surface proteinse
    SA0856aClumping factor AclfA+LPDTG+
    SA2652aClumping factor BclfB+LPETG+
    SA2511aFibronectin binding protein AfnbALPETG+
    SA2509aFibronectin binding protein BfnbBLPETG+
    MW2612gaCollagen adhesioncnaLPKTG
    SA0608aSdrCsdrC+LPETG+
    SA0609aSdrDsdrD+LPETG+
    SA0610aSdrEsdrE+LPETG+
    SA0095a,bProtein AspaLPETG+
    SA0050eMethicillin resistance surface proteinpls+LPDTG+
    SA2676eCell wall surface anchor proteinsasALPDTG
    SA2150ePhosphoglucomutase (FmtB/Mrp)sasBLPDTG+
    SA1806eCell wall surface anchor proteinsasCLPNTG+
    SA0119eCell wall surface anchor proteinsasDLPAAG
    SA1140dCell wall surface anchor proteinsasE (isdA)LPKTG+
    SA2668eCell wall surface anchor proteinsasFLPKAG
    SA2505eCell wall surface anchor proteinsasG (aap)LPKTG+
    SA0024e5′ nucleotidase family proteinsasHLPKTG
    SA1781gCell wall surface anchor proteinsasI (harA)LPKTG+
    SA1138dCell wall surface anchor proteinsasJ (isdB)LPKTG+
    SA2381hdCell wall surface anchor proteinsasKLPKTG
    SA1141eCell wall surface anchor protein (NPQTN)isdCNPQTN
    SA2002aExtracellular adherence proteineap, map
    SA0858aExtracellular matrix and plasma binding proteinempbp
    SA1472aCell wall-associated fibronectin binding proteinebh+
    SA1164aFibrinogen binding-related proteinfib
    SA1168aFibrinogen binding proteinefb
    SA1522aElastin binding proteinebp
    SA1062aBiofunctional autolysinatl
S. epidermidis surface proteinsf
    SE0026aSdrF (truncated) (not all strains have SdrF)sdrF+
    SE0207aSdrGsdrG+LPDTG
    SE1487aSdrHsdrH+
    SE1316eCell wall surface anchor proteinsesALPLAG+
    SE2162eCell wall surface anchor proteinsesBLPNTG
    SE2264eCell wall surface anchor proteinsesCLPATG
    SE2392icCell wall surface anchor proteinsesD (bhp)LPQTG+
    SE0719eCell wall surface anchor proteinsesELPETG+
    SE2398eCell wall surface anchor proteinsesF (aap)LPDTG+
    SE1482ieCell wall surface anchor proteinsesGLPDTG+
    SE1483eCell wall surface anchor proteinsesHLPETG
    SE1654ieCell wall surface anchor proteinsesILPETG
    SE1500jeCell wall surface anchor proteinsesJLPKTG
    SE1501jeCell wall surface anchor proteinsesKLPNTG
    SE1011aCell wall associated fibronectin binding proteinebh+
    SE1048aElastin binding proteinebp
    SE0636a,fBifunctional autolysinaltE
    SE0775aFibrinogen binding proteinfbe
  • a a, adherence to host tissue (extracellular matrix, fibrinogen, fibronectin, collagen, elastin, endothelial and epithelial cells); b, evasion of host defense; c, biofilm formation; d, binding to heme-iron; e, unknown; f, adherence to synthetic material (implanted medical devices); g, haptoglobin receptor A.

  • b SD, Serine-aspartate dipeptide repeats found in staphylococcal cell wall-attached proteins.

  • c LPXTG, attachment sequence for gram-positive cell wall-attached proteins.

  • d YSIRK, signal peptide YSIRK for gram-positive cell wall-attached proteins.

  • e S. aureus COL loci unless indicated otherwise.

  • f S. epidermidis RP62a loci unless indicated otherwise.

  • g S. aureus MW2.

  • h S. aureus N315.

  • i Only in S. epidermidis RP62a.

  • j Only in S. epidermidis ATCC 12228.