TABLE 4.

Surface proteins in S. aureus and S. epidermidis

LocusFunctionaFunctional nameGene(s)SDb presentLPXTGcYSIRKd present
S. aureus surface proteinse
    SA0856aClumping factor A clfA +LPDTG+
    SA2652aClumping factor B clfB +LPETG+
    SA2511aFibronectin binding protein A fnbA LPETG+
    SA2509aFibronectin binding protein B fnbB LPETG+
    MW2612gaCollagen adhesion cna LPKTG
    SA0608aSdrC sdrC +LPETG+
    SA0609aSdrD sdrD +LPETG+
    SA0610aSdrE sdrE +LPETG+
    SA0095a,bProtein A spa LPETG+
    SA0050eMethicillin resistance surface protein pls +LPDTG+
    SA2676eCell wall surface anchor protein sasA LPDTG
    SA2150ePhosphoglucomutase (FmtB/Mrp) sasB LPDTG+
    SA1806eCell wall surface anchor protein sasC LPNTG+
    SA0119eCell wall surface anchor protein sasD LPAAG
    SA1140dCell wall surface anchor protein sasE (isdA)LPKTG+
    SA2668eCell wall surface anchor protein sasF LPKAG
    SA2505eCell wall surface anchor protein sasG (aap)LPKTG+
    SA0024e5′ nucleotidase family protein sasH LPKTG
    SA1781gCell wall surface anchor protein sasI (harA)LPKTG+
    SA1138dCell wall surface anchor protein sasJ (isdB)LPKTG+
    SA2381hdCell wall surface anchor protein sasK LPKTG
    SA1141eCell wall surface anchor protein (NPQTN) isdC NPQTN
    SA2002aExtracellular adherence protein eap, map
    SA0858aExtracellular matrix and plasma binding protein empbp
    SA1472aCell wall-associated fibronectin binding protein ebh +
    SA1164aFibrinogen binding-related protein fib
    SA1168aFibrinogen binding protein efb
    SA1522aElastin binding protein ebp
    SA1062aBiofunctional autolysin atl
S. epidermidis surface proteinsf
    SE0026aSdrF (truncated) (not all strains have SdrF) sdrF +
    SE0207aSdrG sdrG +LPDTG
    SE1487aSdrH sdrH +
    SE1316eCell wall surface anchor protein sesA LPLAG+
    SE2162eCell wall surface anchor protein sesB LPNTG
    SE2264eCell wall surface anchor protein sesC LPATG
    SE2392icCell wall surface anchor protein sesD (bhp)LPQTG+
    SE0719eCell wall surface anchor protein sesE LPETG+
    SE2398eCell wall surface anchor protein sesF (aap)LPDTG+
    SE1482ieCell wall surface anchor protein sesG LPDTG+
    SE1483eCell wall surface anchor protein sesH LPETG
    SE1654ieCell wall surface anchor protein sesI LPETG
    SE1500jeCell wall surface anchor protein sesJ LPKTG
    SE1501jeCell wall surface anchor protein sesK LPNTG
    SE1011aCell wall associated fibronectin binding protein ebh +
    SE1048aElastin binding protein ebp
    SE0636a,fBifunctional autolysin altE
    SE0775aFibrinogen binding protein fbe
  • a a, adherence to host tissue (extracellular matrix, fibrinogen, fibronectin, collagen, elastin, endothelial and epithelial cells); b, evasion of host defense; c, biofilm formation; d, binding to heme-iron; e, unknown; f, adherence to synthetic material (implanted medical devices); g, haptoglobin receptor A.

  • b SD, Serine-aspartate dipeptide repeats found in staphylococcal cell wall-attached proteins.

  • c LPXTG, attachment sequence for gram-positive cell wall-attached proteins.

  • d YSIRK, signal peptide YSIRK for gram-positive cell wall-attached proteins.

  • e S. aureus COL loci unless indicated otherwise.

  • f S. epidermidis RP62a loci unless indicated otherwise.

  • g S. aureus MW2.

  • h S. aureus N315.

  • i Only in S. epidermidis RP62a.

  • j Only in S. epidermidis ATCC 12228.