TABLE 2.

Virulence factors and genomic islands in six sequenced staphylococcal genomes

Virulence factorS. aureusS. epidermidis
COLMu50N315MW2RP62aATCC 12228
Locus and geneIslandLocus and geneIslandLocus and geneIslandLocus and geneIslandLocus and geneIslandLocus and geneIsland
EnterotoxinSA1657 seaSAV2009 sec3vSa4SA1430 seadMW1889 seaφSa3
SA0907 sebvSa1SAV1824 segvSaβSA1817 sec3vSa4MW0759 sec2vSa3
SA0887 seivSalSAV1828 seivSaβSA1642 segvSaβMW1937 segφSa3
SA0886 sekvSalSAV2008 selvSa4SA1646 seivSaβMW0051 seh
SAV1829 semvSaβSA1816 selvSa4MW0760 selvSa3
SAV1825 senvSaβSA1647 semvSaβMW1938 sekφSa3
SAV1830 seovSaβSA1643 senvSaβMW0052 seod
SAV1948 sepφSa3SA1648 seovSaβ
SAV1601 sepSA1761 sepφSa3
SAV1827 seuvSaβSA1645 yent1vSaβ
SA1644 yent2vSaβ
ExotoxinSA1178 set1vSaγSAV0422 set6vSaαSA1009 set1vSaγMW1047 set1vSaγ
SA0469 set1vSaαSAV0423 set7vSaαSA0357 set2MW1048 set4vSaγ
SA0468 set3vSaαSAV0424 set8vSaαSA1011 set3vSaγMW0382 set16vSaα
SA0478 set3vSaαSAV0425 set10vSaαSA1010 set4vSaγMW0383 set17vSaα
SA1180 set3vSaγSAV0426 set11vSaαSA0382 set6vSaαMW0384 set18vSaα
SA0474 set4vSaαSAV0427 set12vSaαSA0383 set7vSaαMW0385 set19vSaα
SA1179 set4vSaγSAV1168 set12vSaγSA0384 set8vSaαMW0386 set20vSaα
SA0473 set5vSaαSAV0428 set13vSaαSA0385 set9vSaαMW0387 set21vSaα
SA0470 setdvSaαSAV0429 set14vSaαSA0386 set10vSaαMW0388 set22vSaα
SA0472 setdvSaαSAV0433 set15vSaαSA0387 set11vSaαMW0389 set23vSaα
SA0388 set12vSaαMW0390 set24vSaα
SA0389 set13vSaαMW0391 set25vSaα
SA0390 set14vSaαMW0394 set26vSaα
SA0393 set15vSaαMW0345 setd
Exfoliative toxinSA1184 etdvSaγSAV1173 etavSaγSA1016 etavSaγMW1054 etavSaγ
Toxic shock syndrome toxinSAV2011 tsstvSa4SA1819 tsstvSa4
EsteraseSA2345SAV2350dSA2140dMW2271dSE1941SE1929
SA2549dSAV2535dSA2323dMW2456dSE2109dSE2095
Serine proteaseSA1869 splAvSaβSAV1813 splAvSaβSA1631 splAvSaβMW1755 splAvSaβ
SA1868 splBvSaβSAV1812 splBvSaβSA1630 splBvSaβMW1754 splBvSaβ
SA1867 splCvSaβSAV1811 splCvSaβSA1629 splCvSaβMW1753 splCvSaβ
SA1866 splDvSaβSAV1810 splDvSaβSA1628 splDvSaβMW1752 splFvSaβ
SA1865 splEvSaβSAV1809 splFvSaβSA1627 splFvSaβMW0903 htrAvSaβ
SA1864 splFvSaβSAV1023 htrASA0879 htrAMW1670 htrA
SA1028 htrASE2390 htrASE0722 htrA
SA1777 htrdSE2401SE0723
StaphylokinaseSAV1944φSa3SA1758φSa3MW1885φSa3
Serine V8 proteaseSA1057 sspASAV1048 sspASA0901 sspAMW0932 sspASE1397 sspASE1543 sspA
Cysteine proteaseSA1056 sspBSAV1047 sspBSA0900 sspBMW0931 sspBSE2390 sspBSE0184 sspB
SA1970 sspBSAV1046 sspCSA0899 sspCMW0930 sspCSE2391 sspCSE0183 sspC
SA1055 sspC
LipaseSA2694 lipSAV2671 lipSA2463 lipMW2590 lipSE2336 lipSE0245 lip
SA0317 geh (amino)aSAV0320 gehSA0309 gehMW0297 gehSE0018 gehSE2403 geh
SA0390 geh (carboxy)aSE2297 geh1, gehCSE0281 geh1, gehC
SE2388 geh2, gehDSE0185 geh2, gehD
Lipase/esteraseSA0712 lipAdSAV0655 lipAdSA0610 lipAdMW0617 lipAdSE0309 lipASE0424 lipA
Extracellular elastasc precursorSE2252 sepASE2219 sepA
Leukotoxin DSA1880 lukDvSaβSAV1819 lukDvSaβSA1637 lukDvSaβMW1767 lukDvSaβ
Leukotoxin ESA1881 lukEvSaβSAV1820 lukEvSaβSA1638 lukEvSaβMW1768 lukEvSaβ
Synergohymenotropic toxinMW1379 lukSPVφSa2
Leukocidin FSA1812 lukFMW1378 lukFPVφSa2
Leukocidin MSA2006 lukMSA1813 lukMMW1942 lukM
Alpha hemolysinSA1173 hlyvSaγSAV1163 hlyvSaγSA1007 hlyvSaγMW0955 hlyvSaγ
Beta hemolysinSA2003 hlbSAV2003 hlbeSA1752 hlbeMW1940 hlbeSE2544 hlbSE0008 hlb
Delta hemolysinSA2022 hldSAV2035 hldSAS065 hldMW1959 hldSE1489 hldSE1634 hld
Gamma hemolysin, component ASA2419 hlgASAV2419 hlgASA2207 hlgAMW2342 hlgA
Gamma hemolysin, component CSA2421 hlgCSAV2420 hlgCSA2208 hlgCMW2343 hlgC
Gamma hemolysin, component BSA2422 hlgBSAV2421 hlgBSA2209 hlgBMW2344 hlgB
Hemolysin IIISA2160dSAV2170SA1973dMW2096dSE1769dSE1760d
HemolysinSA0762dSAV0919SA0780dMW0664dSE2258dSE2226d
Hyaluronate lyaseSA2194 hysASAV2202 hysASA2003 hysAMW2129 hysA
Thermonuclease nucleaseSA1357 nucSAV1324 nucSA1160 nucMW1211 nucSE0891 nucSE1004 nuc
SA0860SAV0815SA0746MW0769SE1570φSPβ
Cell wall hydrolaseSA1264 lytNSAV1247 lytNSA1090 lytNMW1130 lytN
Zinc metalloprotenseSA1281SAV1262SA1105MW1145SE0829dSE0938d
Clp protease, procolytic subunitSA0833 clpPSAV0768 clpPSA0723 clpPMW0730 clpPSE0436 clpPSE0551 clpP
Clp protease, ATP binding subunitSA0979 clpBSAV0975 clpBSA0835 clpBMW0857 clpBSE0564 clpBSE0674 clpB
Clp protease, ATP binding subunitSA1721 clpXSAV1674 clpXSA1498 clpXMW1618 clpXSE1238 clpXSE1349 clpX
Clp protease, ATP binding subunitSA0570 clpCSAV0523 clpCSA2336 clpCMW2469 clpCSE0165 clpCSE0287 clpC
Staphylococcal protein A SpaSA0095 spaSAV0111 spaSA0107 spaMW0084 spa
Phenol-soluble modulinSA1186 betavSaγNT02SA1161 betabvSaγNT01SA1111 betabvSaγMW1056 betavSaγSE0736 beta1vSeγSE0846 beta1vSeγ
SA1187 betavSaγNT02SA1162 betabvSaγNT01SA1112 betabvSaγMW1057 betavSaγSE0737 beta1vSeγSE0847 beta1vSeγ
SA2022 hldcSAV2035 hldcSAS065 hldcMW2121 hldcSE0738 beta1vSeγSE0848 beta1vSeγ
SE0739 beta2vSeγSE0849 beta2vSeγ
SE2397 beta1SE0177 beta
SE2400 beta1SE0174 beta1
SE0083 alpha
SE1489 deltacSE1634 deltac
  • a geh in COL is disrupted by insertion of φCOL near the carboxy terminus of the protein.

  • b Not in original annotation. NT02SA1161, NT025A1162, NT01SA1111, and NT01SA1112 were identified by TIGR annotation.

  • c Also delta hemolysin.

  • d Putative.

  • e Truncated.