TABLE 3.

Ninety-seven ORFs identified as divergent or intermediate in the nonparatuberculosis MAC isolates MAA104, 6004, 6006, 6010, and 6058

RegionORFDescriptionaFunctional category
MAP0034IS900IS element
MAP_RD1MAP0097cAcyl desaturase, N terminalLipid biosynthesis
MAP_RD1MAP0098cTranscriptional regulator, TetR familyConserved hypothetical
MAP_RD1MAP0100GPTase-activating proteinConserved hypothetical
MAP_RD1MAP0101Conserved hypothetical proteinConserved hypothetical
MAP_RD1MAP0102Hypothetical proteinUnknown
MAP_RD1MAP0103cHypothetical proteinUnknown
MAP_RD1MAP0106cIntegrase-recombinasePhage-related function
MAP0159cIS900IS element
MAP0253ISmav2IS element
MAP0284cHypothetical proteinUnknown
MAP0338cSimilar to ISLp1 (GEN: AF386079)IS element
MAP0388Diarylpropane peroxidaseConserved hypothetical
MAP0428Similar to ISmav2 (GEN: AF286339)IS element
MAP0589cSimilar to ISmav2 (GEN: AF286339)IS element
MAP0664cISmav2IS element
MAP0832cSimilar to IS1601-BIS element
MAP_RD2MAP0850cSimilar to ISmav2 (GEN: AF286339)IS element
MAP_RD2MAP0851No hitsUnknown
MAP_RD2MAP0856cNo hitsUnknown
MAP_RD2MAP0859cMycobacterium phage L5Phage-related function
MAP_RD2MAP0866IntegrasePhage-related function
MAP1048cTransposase (GEN: AF373840)IS element
MAP1287Similar to IS1601-BIS element
MAP1432REP family proteinREP13E12 family
MAP1723Putative secreted proteinCell envelope
MAP1822cHypothetical proteinUnknown
MAP1824cTransposase (GEN: X58441)IS element
MAP1946Hypothetical proteinUnknown
MAP1952cSimilar to IS1547IS element
MAP2050Similar to IS1601-BIS element
MAP_RD3MAP2148Integrase-recombinasePhage-related function
MAP_RD3MAP2153No hitsUnknown
MAP_RD3MAP2155Similar to IS6110IS element
MAP_RD3MAP2156Putative transposase (GEN: X52471)IS element
MAP_RD3MAP2158No hitsUnknown
MAP_RD4MAP2179No hitsUnknown
MAP_RD4MAP2181cNo hitsUnknown
MAP_RD4MAP2183cLinalool 8-monooxygenaseConserved hypothetical
MAP_RD4MAP2184cShort-chain alcohol dehydrogenase familyEnergy metabolism
MAP_RD4MAP2185cProline-rich protein precursorUnknown
MAP_RD4MAP2188cAcyl-CoA synthaseDegradation
MAP_RD4MAP2189Cell invasion proteinVirulence
MAP_RD4MAP2190Part of mce4 operonVirulence
MAP_RD4MAP2192Part of mce4 operonVirulence
MAP_RD4MAP2193Part of mce3 operonVirulence
MAP2302ISmav2IS element
MAP2416cSimilar to ISLp1 (GEN: AF386079)IS element
MAP2427cProbable hydrolaseDegradation
MAP2566Similar to ISLp1 (GEN: AF386079)IS element
MAP_RD5MAP2755Hypothetical proteinUnknown
MAP_RD5MAP2756cHypothetical proteinUnknown
MAP_RD5MAP2758Hypothetical proteinUnknown
MAP_RD5MAP2759Conserved hypothetical proteinConserved hypothetical
MAP_RD5MAP2764cNo hitsUnknown
MAP_RD5MAP2765cNo hitsUnknown
MAP_RD5MAP2767cNo hitsUnknown
MAP_RD5MAP2768cPhiRV2 integrasePhage-related function
MAP2963cNo hitsUnknown
MAP2964cHypothetical proteinUnknown
MAP3078cTransposase (GEN: AF373840)IS element
MAP3357cSimilar to ISLp1 (GEN: AF386079)IS element
MAP3436cHypothetical proteinUnknown
MAP3437cNo hitsUnknown
MAP3467cSimilar to ISLp1 (GEN: AF386079)IS element
MAP_RD6MAP3726Iron ABC transporterTransport-binding proteins
MAP_RD6MAP3727ABC transporter proteinCell envelope
MAP_RD6MAP3729DioxygenasediooxygenaseEnergy metabolism
MAP_RD6MAP3731cABC transporter ATP-binding subunitTransport-binding proteins
MAP_RD6MAP3732cCobalt permease and related transportersTransport-binding proteins
MAP_RD6MAP3733cHypothetical proteinUnknown
MAP_RD6MAP3734cABC transporter ATP-binding proteinCell envelope
MAP_RD6MAP3736cHeavy metal tolerance proteinConserved hypothetical
MAP_RD6MAP3738cConserved hypothetical proteinConserved hypothetical
MAP_RD6MAP3739cPossible sugar transporterCell envelope
MAP_RD6MAP3741Putative nonribosomal peptide synthaseNonribosomal peptide synthesis
MAP_RD6MAP3742Putative nonribosomal peptide synthaseNonribosomal peptide synthesis
MAP_RD6MAP3743Hypothetical proteinUnknown
MAP_RD6MAP3745ThioesteraseConserved hypothetical
MAP_RD6MAP3747cConserved hypothetical proteinConserved hypothetical
MAP_RD6MAP3748cSimilar to IS1110IS element
MAP_RD6MAP3751Conserved large membrane proteinCell envelope
MAP_RD6MAP3753Hypothetical proteinUnknown
MAP_RD6MAP3754Similar to transposase of IS3 familyIS element
MAP_RD6MAP3755Similar to transposaseIS element
MAP_RD6MAP3762cPossible rhamnosyl-glycosyl-transferaseMiscellaneous transferases
MAP_RD6MAP3764cPolyketide synthaseNonribosomal peptide synthesis
MAP_RD6MAP3766Membrane proteinConserved hypothetical
MAP_RD6MAP3770Conserved hypothetical proteinConserved hypothetical
MAP_RD6MAP3772cConserved hypothetical proteinConserved hypothetical
MAP_RD6MAP3775cPutative ABC transporter ATP-binding proteinTransport-binding proteins
MAP_RD7MAP3815No hitsUnknown
MAP_RD7MAP3816Hypothetical proteinUnknown
MAP_RD7MAP3817cNo hitsUnknown
MAP_RD7MAP3818Cytochrome P450Cytochrome P450 enzymes
MAP4270Multicopy phage resistance protein MprConserved hypothetical
MAP4280Cholesterol oxidaseDegradation
  • a Abbreviations: GEN, GenBank sequence accession number; CoA, coenzyme A.