TABLE 2.

Strain 86-028NP genes encoding proteins with a role in lipooligosaccharide biosynthesis

NTHi no.aHI no.bGene nameFunctionContingency repeats
6858kdsB3-Deoxy-d-manno-octulosonic acid cytidylyltransferase
6959lpxKTetraacyldisaccharide 4′-kinase
7260msbALipid A export ATP-binding protein msbA
296199msbBLipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase
365258lgtCUDP-galactose-lipooligosaccharide galactosyltransferaseGACA repeated 10 times, in frame
366260orfMXanthosine triphosphate pyrophosphatase
367260.1kdkA3-Deoxy-d-manno-octulosonic acid kinase
368261opsXADP-heptose-lipooligosaccharide heptosyltransferase I
383275lpt6PE-tn-6-lipooligosaccharide phosphorylethanolamine transferase
471351galEUDP-glucose 4-epimerase
472352lic3ACMP-Neu5Ac-lipooligosaccharide alpha-2-3-sialyltransferaseCAAT repeated 18 times, in frame
512391Predicted acyltransferaseAGCA repeated 8 times, in frame
649523waaQADP-heptose-lipooligosaccharide heptosyltransferase III
677550lic2AUDP-galactose-lipooligosaccharide galactosyltransferaseCAAT repeated 14 times, in frame
772652kdtA3-Deoxy-d-manno-octulosonic acid transferase
773653lgtFUDP-glucose-lipooliqosaccharide glucosyltransferase
892735lpxHUDP-2,3-diacylglucosamine hydrolase
899740pgmBPhosphoglucomutase
913lex2BUDP-glucose-lipooliqosaccharide glucosyltransferase
926765lpsALipooligosaccharide glycosyltransferase
976812qalUUTP-glucose-1-phosphate uridylyltransferase
1034lic3A2CMP-Neu5Ac-lipooligosaccharide alpha-2-3-sialyltransferaseCAAT repeated 18 times, in frame
1037873rmlBdTDP-glucose 4,6-dehydratase
1082915lpxDUDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase
11801005Predicted PE-lipooligosaccharide phosphorylethanolamine transferase
12201060lpxBLipid-A-disaccharide synthase
12221061lpxAAcyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase
12241064Predicted PE-lipooligosaccharide phosphorylethanolamine transferase
12721105rfaFADP-heptose-lipooligosaccharide heptosyltransferase II
12781114rfaDADP-l-glycero-d-manno-heptose-6-epimerase
13121144lpxCUDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase
13501181lpcAPhosphoheptose isomerase
14741578lgtDPutative UDP-GlcNAc-lipooligosaccharide N-acetylglucosamine glycosyltransferase
15761557kdsAPhospho-2-dehydro-3-deoxyoctonate aldolase and 3-deoxy-d-manno-octulosonic add 8-phosphate synthetase
15941540licDPhosphorylcholine transferase
15951539licCProtein LicC, CTP-phosphocholine cytidylyltransferase
15961538licBProtein LicB, putative choline uptake protein
15971537licAProtein LicA, choline kinaseCAAT repeated 15 times, in frame
16061527htrBLipid A biosynthesis lauroyl acyltransferase
16071526rfaEADP-heptose synthase
16641337mrsAPredicted phosphomannomutase
1750Putative glycosyltransferase, glycosyltransferase family 8 proteinGACA repeated 14 times, in frame
1769Putative glycosyltransferaseCCAA repeated 17 times, out of frame
18911279slaBCMP-Neu5Ac synthetase
19211244Possible polysaccharide biosynthesis protein
20021695lsgFPutative UDP-galactose-lipooligosaccharide galactosyltransferase
20031696lsgEPutative UDP-galactose-lipooligosaccharide galactosyltransferase
20041697lsgDPutative UDP-GlcNAc-lipooligosaccharide N-acetylglucosaminyl glycosyltransferase
20051698lsgCPutative UDP-galactose-lipooligosaccharide galactosyltransferase
20061699lsgBCMP-N-acetylneuramlnate-beta-galactosamide-alpha-2,3-sialyltransferase
20071700lsgAPutative lipooligosaccharide flippase
20251716wecAUndecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase
  • a Assigned locus number for each strain 86-028NP gene listed.

  • b Locus number assigned by TIGR for the corresponding Rd homolog.