TABLE 4.

Functional classes of genes that are significantly overrepresented in the lifestyle regions (2.70 to 2.85 Mb and 3.10 to 3.29 Mb)

Functional categoryNo. of genes in:% in lifestyle regionsOverrepresentation (fold)aP valueb
Lifestyle regionsTotal chromosome
Energy metabolism; sugars2858485.07.9E-13
Transport and binding proteins; PTS systems2567373.92.6E-09
Regulatory functions; two-component regulators1131353.75.6E-05
Regulatory functions; LacI family regulators715474.91.2E-04
Transport and binding proteins; carbohydrates, organic alcohols, and acids1244272.93.9E-04
Cell envelope; cell surface proteins, other1457252.64.7E-04
Regulatory functions; other1569222.31.2E-03
Regulatory functions; BglB family regulators35606.31.5E-03
Energy metabolism; aerobic936252.62.8E-03
Regulatory functions; AraC family regulators37434.54.9E-03
Energy metabolism; pentose phosphate pathway517293.16.3E-03
Energy metabolism; phenolic acids38383.97.7E-03
Regulatory functions; TetR/AcrR family regulators625242.50.01
  • a Overrepresentation in lifestyle regions was calculated using the null hypothesis that a proportional part of the total number of genes in a functional category may be expected in the lifestyle regions. The proportionality constant used was equal to the number of genes in the lifestyle region, 293, divided by the total number of genes in the chromosome, 3,064.

  • b Significance of overrepresentation was calculated using the cumulative binomial distribution with a probability of success equal to the proportion of genes present genomewide in the particular category.