TABLE 1.

Allelic profiles and STs of strains used in this work

Strain IDAllele assignmentSerotypebOptochin sensitivitycSite of isolationd
aroEgdhgkirecPspixptddlSTaplya
IOPR 58771545538151+NP
IOKOR 818512291293918100133+NP
IOPR 1128512291293918100133+MEF
IOPR 1295512291293918100133+NP
IOPR 3524512291293918100133+NP
IOPR 5853512291293918100133+NP
IOPR 868512291293918100133+NP
IOPR 13877585106141382+NP
IOPR 3071711101681416239V+NP
IOPR 3942711101681416239V+NP
IOPR 3399813144174141991+NP
IOPR 587815881815131235720+NP
IOPR 1329837929212533441+NP
IOPR 1734837929212533441+MEF
IOPR 1746837929212533441+NP
IOPR 2052837929212533441+NP
IOPR 2257837929212533441+NP
IOPR 2302837929212533441+MEF
IOPR 4124837929212533441+NP
IOPR 4125837929212533441+NP
IOPR 4169837929212533441+MEF
IOPR 4573837929212533441+NP
IOPR 4848837929212533441+NP
IOPR 6449837929212533441+MEF
IOKOR 105185227211714484+NP
IOKOR 185885227211714484+NP
IOKOR 29485227211714484+MEF
IOKOR 54385227211714484+MEF
IOKOR 76885227211714484+NP
IOPR 12985227211714484+MEF
IOPR 142285227211714484+NP
IOPR 274085227211714484+MEF
IOPR 285185227211714484+MEF
IOPR 359585227211714484+NP
IOPR 4885227211714484+MEF
IOPR 558085227211714484+MEF
IOPR 594485227211714484+NP
IOPR 596685227211714484+NP
IOPR 607385227211714484+MEF
IOPR 149683792924754491+MEF
IOPR 158683792924754491+NP
IOPR 179383792924754491+NP
IOPR 236883792924754494+NP
IOPR 268783792924754491+NP
IOPR 286683792924754491+NP
IOPR 301483792924754491+NP
IOPR 306583792924754491+NP
IOPR 322383792924754491+NP
IOPR 393383792924754491+MEF
IOPR 413183792924754491+NP
IOPR 418483792924754491+NP
IOPR 429383792924754491+NP
IOPR 484783792924754491+NP
IOPR 502783792924754491+NP
IOPR 559983792924754491+NP
IOPR 574583792924754491+NP
IOPR 584483792924754491+NP
IOKOR 10547511631949216B+NP
IOKOR 492138651601665088+NP
IOKOR 609138651601665088+NP
IOKOR 707138651601665088+NP
IOKOR 3141141181617520122F+NP
IOKOR 3281141181617520122F+MEF
IOKOR 3451141181617520122F+MEF
IOPR 40361141181617520122F+NP
IOPR 52688379292475910541+NP
IOPR 261975858761410552+NP
IOPR 48498522721367112294+MEF
IOPR 28372529164231461248133+NP
IOPR 193852279117112904+MEF
IOKOR 22AABBBHBNT1NT1+NP
IOPR 1711AEC29FCENT2NT5+NP
IOKOR 98AEEDDFBNT3NT7+NP
IOKOR 213AFFFEBBNT4NT1+NP
IOPR 418AGCEBHBNT5NT1NP
IOPR 870AHGHFGBNT6NT1NP
IOPR 2017AJDHBRGNT7NT4+NP
IOPR 5427ALCMEBBNT8NT1+NP
IOKOR 898AOCEFBGNT9NT9+NP
IOPR 6117B40ANIAGNT10NT3+NP
IOKOR 50ABCCCHBNT11NT11+NP
IOKOR 534B57GPIMBNT12NT2+NP
IOKOR 56BCAAAQANT13NT1+NP
IOKOR 8BCAAAQANT13NT1+NP
IOPR 1791BJHJFDFNT14NT1+NP
IOKOR 809BNJQJLBNT15NT8+NP
IOKOR 332CDF29IB49NT17NT1+NP
IOKOR 731CFDRKCHNT18NT6+MEF
IOKOR 220CGBGFJBNT19NT1+NP
IOKOR 226ADBHFBBNT20NT1+NP
IOKOR 290ADBHFBBNT20NT1+NP
IOPR 1386CICGGEBNT21NT1NP
IOKOR 254D57DIEIDNT22NT2+NP
IOPR 2717EICGGEBNT23NT1+NP
IOPR 923EICGGEBNT23NT1+NP
IOKOR 106ADCEBHCNT24NT1+NP
IOPR 5370ADCLFCENT25NT1+NP
IOKOR 4845MJO6GBNT26NT5+NP
IOPR 3458ADCDDBHBNT27NT1+NP
IOPR 2716ADCEBHONT28NT1+NP
IOKOR 769ADDBBHBNT29NT1+NP
IOPR 3101AEBDOFBNT30NT7+NP
IOPR 3074AIHWEBLNT31NT10NP
IOKOR 78ADDBBKBNT32NT1+NP
IOPR 5052AOPBFBGNT33NT9+NP
IOPR 2640AY41MBBNT34Mixed+NP
IOKOR 1148BRAJIKENT35NT3+NP
IOKOR 1674BRANIUPNT36NT3+NP
IOPR 3582BRANIUPNT36NT3+NP
IOKOR 1096ADCCCFCENT37NT1+NP
IOKOR 937ADCCCFCENT37NT1+NP
IOKOR 545ADCBMBBNT38NT12+NP
IOKOR 675ADCBMBBNT38NT12+NP
IOKOR 869ADCBBHBNT39NT13+NP
IOPR 1260AEBDDFBNT40NT7+NP
IOKOR 1362AEBDD1BNT41NT7+MEF
IOKOR 485CSLGFNDBNDNT1+NP
IOKOR 810CSLGFNDBNDNT1+NP
IOPR 2148NDKIKXRKNDNDNP
  • a NT is used as a prefix to distinguish between true pneumococci and the related isolates shown in Fig. 1 (groups 1 and 2). ND indicates that it was not possible to obtain a sequence for this locus from this isolate. One isolate gave a mixed sequence for ply.

  • b All isolates were nontypeable on first inspection, but where a serotype was found on subsequent analysis, this is indicated in parentheses.

  • c + indicates that the isolate was optochin sensitive; − indicates that it was resistant.

  • d NP, retrieved from nasopharyngeal carriage; MEF, obtained from middle ear fluid of children suffering from otitis media.