TABLE 4.

Candidate orfs for virulence found in S. haemolyticus JCSC1435

orf IDLocationaPhylogenetic classbGene nameProduct
SH0040SCCSHHypothetical protein, similar to surface protein SdrI from Staphylococcus saprophyticus
SH0170oriC environSHHypothetical protein, similar to serine protease SplF
SH0282oriC environSASHnanASialic acid lyase
SH0305oriC environSASESH67-kDa myosin-cross-reactive antigen homologue
SH0326oriC environSHStreptococcal hemagglutinin-like protein
SH0362oriC environSHHypothetical protein, similar to immunodominant antigen B
SH0365oriC environSHHypothetical protein, similar to immunodominant antigen B
SH0388-SH0400oriC environSH, SASHcapA-MCapsular polysaccharide synthesis enzymes
SH0423oriC environSASESHHypothetical protein, similar to secretory antigen precursor SsaA
SH0486oriC environSHHypothetical protein, similar to immunodominant antigen
SH0512oriC environSASESHHypothetical protein, similar to secretory antigen precursor SsaA
SH0531-SH0533oriC environSESH. SHpgsA-CPoly-gammma-glutamate synthesis enzymes
SH0635oriC environSHHypothetical protein, similar to SceA precursor from Staphylococcus camosus
SH0682SHHypothetical protein, similar to a protein involved in attachment to host cells and virulence
SH0750SHatlEAdhesin enzyme
SH0755SHHypothetical protein, similar to secretory antigen precursor SsaA
SH0782SASESHSecretory antigen precursor SsaA homologue
SH0871SASESHHypothetical protein, similar to hemolysin III
SH0939SHHypothetical protein, similar to immunodominant antigen SceD precursor from Staphylococcus camosus
SH0999SHHypothetical protein, similar to serine-aspartate repeat protein SdrZ
SH1134SASESHHypothetical protein, similar to α-hemolysin
SH1158SASESHLysophospholipase
SH1165SHHypothetical protein, similar to FmtB/extracellular matrix binding protein
SH1166SHHypothetical protein, similar to FmtB protein
SH1251SASESHclpXClpX protease
SH1363SASESHsodASuperoxide dismutase
SH1431SHebpSCell surface elastin binding protein EbpS
SH1471SHHypothetical protein, similar to hemagglulinin/hemolysin-related protein
SH1561SHHypothetical protein, similar to exonuclease SbcC
SH1562SHHypothetical protein, similar to exonuclease SbcD
SH1688SHHypothetical protein, similar to staphylococcal nuclease
SH1706SASESHHypothetical protein, similar to fibronectin/fibrinogen-binding protein
SH1719SHHypothetical protein, similar to secretory antigen SsaA
SH1773φSh1SHClpP-like protease
SH1936SHHypothetical protein, similar to serine protease HtrA
SH2121SASESHATP-dependent Clp protease proteolytic subunit homologue
SH2193SASESHHypothetical protein, similar to hemolysin
SH2229SHSecretory antigen SsaA homologue
SH2426SHHypothetical protein, similar to putative cell-surface adhesin SdrF
SH2429SHFibrinogen-binding protein SdrG (truncated)
SH2430SHFibrinogen-binding protein SdrG (truncated)
SH2431SHHypothetical protein, similar to fibrinogen-binding protein SdrG (truncated)
SH2617πSh2SESHHypothetical protein, similar to immunodominant antigen B
  • a Those on genomic islands are indicated.

  • b Phylogenetic class of homologs as defined in Fig. 2a. Some JCSC1435 orfs that even have homologous orfs in other species are denoted as SH if the nucleotide sequence identify of the orfs is less than 70% (see Materials and Methods for the definition of homologs).