TABLE 3.

Susceptibility to antibiotics and the genes conferring resistance of S. haemolyticus JCSC1435

ClassAntimicrobial agentMIC (mg/liter)Resistance gene(s)
orf IDGene nameProductLocation
PenicillinsOxacillin>512SH0091mecAPenicillin-binding protein 2′ΨSCCmec(h1435)
Ampicillin64SH1764blaZβ-LactamaseTn552
CephalosporinsCeftizoxime>512SH0091mecAPenicillin-binding protein 2′ΨSCCmec(h1435)
MacrolidesErythromycin>512pSHaeB1ermCrRNA adenine N-6-methyltransferasePlasmid pSHaeB
SH2305msrSAATP-dependent efflux systemπSh1
SH2306mphBMMacrolide 2′-phosphotransferaseπSh1
QuinolonesOfloxacin8SH0006gyrADNA gyrase (topoisomerase II) subunit A (point mutation C7313Ta)
SH1553parC (grlA)Topoisomerase IV subunit A (point mutation G1598138Ab)
TetracyclinesTetracycline2
Minocycline0.5
AminoglycosidesKanamycin>512SH1611aacA-aphDBifunctional aminoglycoside N-acetyltransferase and aminoglycoside phosphotransferaseTn4001
Tobramycin16SH1611aacA-aphDBifunctionalTn4001
Gentamicin64SH1611aacA-aphDBifunctionalTn4001
GlycopeptidesVancomycin4
Teicoplanin64
FosfomycinFosfomycin>512pSHaeA1fosBGlutathione transferasePlasmid pSHaeA
  • a Point mutation from C to T at bp 7313 in JCSC1435 confers resistance.

  • b Point mutation from G to A at bp 1598138 in JCSC1435 confers resistance.