TABLE 1.

MICs (in micrograms/milliliter) of compounds during induction of yhcS antisense with or without ATc

Compound and activityWCUH29/pYH3JSAS909
Without ATcWith ATc (250 ng/ml)Without ATcWith ATc (250 ng/ml)
DNA synthesis
    Quinacrine 2 HCl>64>64>64>64
    Novobiocin0.1250.1250.1250.125
RNA transcription
    Rifampin0.060.060.060.06
Translation
    Chloramphenicol8888
    Kanamycin64646464
    Erythromycin>64>64>64>64
Cell wall biosynthesis
    Phospomycin8881
    Vancomycin0.5110.5
    Bacitracin>64>64>64>64
    Polymyxin B>64>64>64>64
Lipid biosynthesis
    Cerulenin64646464
Electron transporter
    Oligomycin>64>64>64>64