TABLE 4.

Characteristics of M. avium subsp. avium-specific (MAV) genomic islands

IslandNo. of ORFs% GCIsland typeSize (bp)Signature feature(s)
MAV-13868.93I39,833Eukaryotic genes with an integrase gene
MAV-23265.87I31,387Transposition and M. tuberculosis genes
MAV-31063.34I9,693Insertion sequence and M. tuberculosis or M. avium genes
MAV-45366.83I47,356PPE family and eukaryotic genes
MAV-51664.10I17,905Transposition and insertion sequences genes
MAV-62368.80I19,161Transposition, transcriptional regulator and heavy metal resistance genes
MAV-718765.50II196,411Transposition, transcriptional regulators, cell entry and iron regulation genes
MAV-8365.18I2,977Transposition and transcriptional regulator genes
MAV-91562.43I20,844Transposition and type III restriction system endonuclease genes
MAV-101263.87I12,491Transposition genes
MAV-11565.45I3,593Reductases and hypothetical proteins
MAV-1216865.05II181,445Transposition, transcriptional regulators and cell entry genes
MAV-13767.78II5,525Transcriptional regulator
MAV-142667.32I28,265Transposition and M. tuberculosis genes
MAV-15364.12II4,731Streptomyces and M. leprae genes
MAV-16669.64I44,157Transposition and Pst genes
MAV-172065.23II21,219Transposition and drrAB genes (antibiotic resistance)
MAV-18468.13I3,918Transcriptional regulator and Streptomyces genes
MAV-19465.30I5,169Transposition genes
MAV-201563.93I21,283Transposition, transcriptional regulator and membrane-protein genes of M. tuberculosis
MAV-21865.93I6,895Transposition and antigen genes
MAV-22967.71I9,931Transcriptional regulator and metalloprotease genes
MAV-237764.08I95,547Transposition, transcriptional regulators, secreted proteins and cell entry genes
MAV-241870.25I16,200Hypothetical and unknown proteins from M. tuberculosis and Streptomyces spp.
Total759845,936