TABLE 2.

Cefotaxime resistance and competence of PBP2x and/or CiaH mutants

StrainMutationMIC CTXCompetence
CiaHPBP2x
C206D597/V6010.12+
R6pbp2xC203D5970.07+
R6pbp2xC303D597/A5500.2+
R6pbp2x681Mosaica0.2+
R6pbp2x8249Mosaica0.2+
C103pbp2x681V203Mosaica0.25b
C103pbp2x8249V203Mosaica0.3
R6ciaHC306P2300.04
  • a The mosaic pbp2x genes of the clinical isolates S. pneumoniae 681 and 8249 contained multiple alterations.

  • b Transformation efficiency of <10−5 compared to that of the R6 strain.