TABLE 2.

HP1021-activated and -repressed genes

Category and ORF HP no.bORF JHP no.bΔhp1021/wild-type ratioFunction, genecGenome organizationdRegulation by acid or ArsR∼P (reference[s])e
HP1021-activated genesa
    Amino acid biosynthesis
        HP0695JHP06330.06Hydantoin utilization protein A, hyuAop hp0695-hp0697+ (39), − (20)
        HP0696JHP06320.08Predicted N-methylhydantoinaseop hp0695-hp0697
    Biosynthesis of cofactors, prosthetic groups, and carriers
        HP0220JHP02060.39Synthesis of [Fe-S] cluster, nifSop hp0220-hp0221
        HP0221JHP02070.37NifU scaffold protein involved in [Fe-S] cluster assemblyop hp0220-hp0221
    Cell envelope
        HP0025JHP00210.19Outer membrane protein, omp2 (hopD)m+ (39)
        HP1564JHP14720.36Outer membrane lipoproteinm+ (30)
    Cellular processes
        HP0875JHP08090.25Catalase, katAm+ (30, 39)
        HP0303JHP02880.43Predicted GTP-binding protein of the GTP1/Obg family involved in stress responseop hp0298-hp0304
        HP0630JHP05730.48Predicted modulator of drug activitym
    Energy metabolism
        HP0691JHP06370.18Succinyl-CoA:acetoacetate-CoA-transferase subunit A, scoA (yxjD)op hp0690-hp0693
        HP0692JHP06360.18Succinyl-CoA:acetoacetate-CoA-transferase subunit B, scoB (yxjE)op hp0690-hp0693+ (39)
        HP1104JHP10300.49Predicted mannitol dehydrogenasem+ (30, 39)
        HP1398JHP14280.41Alanine dehydrogenase, aldm− (30)
    Fatty acid and phospholipid metabolism
        HP0090JHP00830.36Predicted malonyl coenzyme A-acyl carrier protein transacylase, fabDop hp0090-hp0089
        HP0690JHP06380.47Predicted acetyl coenzyme A acetyltransferase, fadAop hp0690-hp0693+ (39)
    Central intermediary metabolism
        HP0089JHP00820.46Predicted 5′-methylthioadenosine nucleosidase/ S-adenosylhomocysteine nucleosidase, pfsop hp0090-hp0089
        HP1186JHP11120.42Carbonic anhydrasem+ (39), − (20)
    Protein fate
        HP1299JHP12190.39Predicted methionine amino peptidaseop hp1320-hp1292?
        HP1300JHP12200.41Predicted preprotein translocase subunitop hp1320-hp1292?
    Transcription, transcription factors, and translation
        HP1514JHP14070.45Transcription termination factor, nusAm
        HP1301JHP12210.44Ribosomal protein, rpl15op hp1320-hp1292?
        HP1302JHP12220.47Ribosomal protein, rps5op hp1320-hp1292?
        HP1303JHP12230.48Ribosomal protein, rpl18op hp1320-hp1292?− (39)
        HP1304JHP12240.34Ribosomal protein, rpl6op hp1320-hp1292?
        HP1305JHP12250.37Ribosomal protein, rps8op hp1320-hp1292?− (39)
        HP1306JHP12260.45Ribosomal protein, rps14op hp1320-hp1292?
        HP1307JHP12270.40Ribosomal protein, rpl5op hp1320-hp1292?− (39)
        HP1308JHP12280.39Ribosomal protein, rpl24op hp1320-hp1292?
        HP1309JHP12290.44Ribosomal protein, rpl14op hp1320-hp1292?− (39)
        HP1310JHP12300.44Ribosomal protein, rps17op hp1320-hp1292?
        HP1313JHP12330.34Ribosomal protein, rps3op hp1320-hp1292?
        HP1314JHP12340.37Ribosomal protein, rpl22op hp1320-hp1292?