TABLE 4.

Genes down-regulated in N. gonorrhoeae strain MS11-A after heat shock at 42°C for 10 min

Open reading frameaGeneFold changebProposed functionc
NGO1235 ilvH 0.38Acetolactate synthase III, small subunit
NGO04100.38Putative transcriptional regulator CspA
NGO1236 ilvI 0.42Acetolactate synthase III, large subunit
NGO1473 mdaB 0.44Modulator of drug activity
NGO12340.56Hypothetical protein
NGO1233 ilvC 0.56Ketol-acid reductoisomerase
NGO0233 nsgA 0.57Outer membrane protein
NGO1980 yojH 0.61Malate:quinone oxidoreductase
NGO1415 nqrC 0.62NADH-quinone reductase, subunit C
NGO14490.65Putative l-lactate permease
NGO05630.65Hypothetical protein
NGO09040.66Conserved hypothetical protein
NGO1406 gcvT 0.66Aminomethyl transferase
  • a Designations from the annotation at www.ncbi.nlm.nih.gov/entrez/query.fcgi .

  • b The fold change is the average expression ratio for genes that were down-regulated at least 1.5 fold with a P value of <0.001.

  • c Proposed functions of the genes based on sequence annotation, sequence homology, and previous investigations.