TABLE 3.

H. pylori genes selected for analysis using a yeast two-hybrid system

H. pylori 26695 geneProteinAgrobacterium homologueIdentified by 2D-DIGEaNecessary for CagAp-Tyra,bNecessary for IL-8 secretiona,b
HP0522Cag3+++
HP0524Cag5VirD4+
HP0525VirB11/ATPaseVirB11+++
HP0526CagZ/6+
HP0527CagY/7VirB10++
HP0528CagX/8VirB9+++
HP0530CagV/10VirB8++
HP0532CagT/12VirB7++
HP0534CagS/13+
HP0537CagM/16+++
HP0540CagI/19+
HP0542CagG/21+
HP0543CagF/22+
HP0544CagE/23/PicBVirB4++
  • a +, yes; −, no.

  • b Based on analysis of interactions between H. pylori strain 26695 and AGS cells (27).