TABLE 4.

Dual regulation of lincomycin resistance and quercetin 2,3-dioxygenase synthesis by LmrA and YxaF

StrainDisrupted gene(s)Mean lincomycin IC50 (μg/ml) ± SDaQuercetin 2,3-dioxygenase concn (μmol/min per mg protein) ± SDa
168None14.6 ± 5.00.0004 ± 0.0002
FU875yxaF15.6 ± 5.10.0368 ± 0.0126
PLR2lmrA170.5 ± 55.90.145 ± 0.024
FU899lmrA and yxaF196.4 ± 53.90.568 ± 0.136
  • a Data represent the mean values ± standard deviations obtained in three independent experiments.