TABLE 2.

Potential virulence genes targeted for mutagenesis

B. mallei CDSProductaRationale for targetingVirulence of mutant in larvaeb
BMA02353-Phosphoshikimate 1-carboxyvinyltransferaseBest BLASTP hit in phylogenetically distant pathogenReduced
BMA0847Galactose oxidase-related proteinBest BLASTP hit in eukaryoteNormal
BMA1123Peptide synthetasePossible role in cytotoxin productionNormal
BMAA1013ECF sigma factorPotential virulence gene regulatorNormal
BMAA1111Hypothetical proteinBest BLASTP hit in eukaryoteNormal
BMAA1204Putative PKSPossible role in cytotoxin productionReduced
BMAA1517AraC family transcriptional regulatorPotential virulence gene regulatorReduced
BMAA1621Regulatory protein HrpBPotential virulence gene regulatorNormal
BMAA1785Chitin binding domain proteinBest BLASTP hit in phylogenetically distant pathogenReduced
BMAA1900Pentapeptide repeat family proteinBest BLASTP hit in phylogenetically distant pathogenReduced