TABLE 2.

MICs of lipophilic agents in LB and divalent cation-depleted LB (LB with 1 mM EDTA)

StrainMutations presentMIC (μg/ml) of:
ErythromycinNovobiocinRifampinFusidic acidApramycin
No EDTA1 mM EDTANo EDTA1 mM EDTANo EDTA1 mM EDTANo EDTA1 mM EDTANo EDTA1 mM EDTA
HN1139phoP::Tn10d-cam tolC40.060.50.0164<0.004>20.008168
HN1140pho-24 tolC4110.13>40.520.253232
HN1142pho-24 lpxO tolC rpsL40.510.13>40.520.253232
HN1143pho-24 pagP tolC rpsL40.510.13>40.2520.133232
HN1147pho-24 pmrA::Tn10d-tet tolC rpsL40.510.13>40.520.253232
HN1144pho-24 lpxO pagP tolC rpsL40.510.13>40.2520.133232
HN1148pho-24 lpxO pagP pmrA::Tn10d-tet tolC rpsL40.250.50.03>40.2520.063232