Table 4.

Enzymes in the biosynthetic pathways of E. rhusiopathiae

Category or compound (gene)Locus tag(s)
Energy metabolism
    Glycolysis
        Glucokinase (glk)ERH_0239, ERH_1009
        Glucose-6-phosphate isomerase (pgi)ERH_0099
        6-Phosphofructokinase (pfkA)ERH_1011, ERH_1051
        Fructose-bisphosphate aldolase (fba)ERH_1632
        Triose-phosphate isomerase (tpiA)ERH_1335
        Glyceraldehyde 3-phosphate dehydrogenase (gapA)ERH_1534
        Phosphoglycerate kinase (pgk)ERH_1336
        Phosphoglycerate mutase (gpmA)ERH_0241, ERH_0435, ERH_0457, ERH_1685
        Enolase (eno)ERH_1334
        Pyruvate kinase (pyk)ERH_1010
    Pentose phosphate pathway
        Glucose-6-phosphate 1-dehydrogenase (zwf)ERH_0455
        6-Phosphogluconolactonase (pgl)ERH_0398
        6-Phosphogluconate dehydrogenase (gnd)ERH_0456
        Transketolase (tkt)ERH_1578
        Ribose 5-phosphate isomerase (rpiB)ERH_1609
        Ribulose-phosphate 3-epimerase (rpe)ERH_1027
    TCA cycle
        Fumarate hydratase (fumC)ERH_0730
Amino acid biosynthesis
    Proline
        Glutamate 5-kinase (proB)ERH_0054
        Glutamate-5-semialdehyde dehydrogenase (proA)ERH_0055
        Pyrroline-5-carboxylate reductase (proC)ERH_0057
    Glutamine
        Glutamine synthetase (glnA)ERH_0836
    Alanine
        Alanine dehydrogenase (ald)ERH_1073
    Asparagine
        Aspartate-ammonia ligase (asnA)ERH_1353
    Cysteine
        Serine O-acetyltransferase (cysE)ERH_0421
        Cysteine synthase A (cysK)ERH_0469
    Serine
        l-Serine dehydratase (sdaA)ERH_1322
        l-Serine dehydratase (sdaB)ERH_1323
    Glycine
        Glycine hydroxymethyltransferase (glyA)ERH_1608
    Arginine (incomplete pathway)
        Arginine deiminase (arcA)ERH_0795
        Carbamate kinase (arcC)ERH_0797
        Ornithine carbamoyltransferase (argF)ERH_0796
Cofactors, vitamins, prosthetic groups and carriers
    Pantothenate (incomplete pathway)
        2-Dehydropantoate 2-reductase (panE/apbA)ERH_1317
    CoA
        Type III pantothenate kinase (coaX)ERH_0124, ERH_0188
        Phosphopantothenate-cysteine ligase (coaB)ERH_0126
        Phosphopantothenoylcysteine decarboxylase (coaC)ERH_0125
        Pantetheine-phosphate adenylyltransferase (coaD)ERH_1118
        Dephospho-CoA kinase (coaE)ERH_1014
    Folate (incomplete pathway)
        Folylpolyglutamate synthase (folC)ERH_1520
        Dihydrofolate reductase (folA)ERH_0263, ERH_0996
    Thiamine (incomplete pathway)
        Cysteine desulfuraseERH_0498, ERH_0508
        Nucleoside-triphosphataseERH_0545
        Thiamine biosynthesis protein (thiI)ERH_0509