Table 8.

Possible virulence factors of E. rhusiopathiae

Locus tagGenePredicted function and/or descriptionMotif/modulesa
Surface proteins
    ERH_0075Collagen-binding proteinLPXTG
    ERH_0094spaA.1Unknown, protective antigenGW
    ERH_0150hylAHyaluronidaseLPXTG
    ERH_0161Peptidase M14LPXTG
    ERH_0201Pectin lyase fold-containing proteinLPXTG
    ERH_0221Glycoside hydrolase, family 16LPXTG
    ERH_0260ProteinaseLPXTG
    ERH_0278UnknownLPXTG
    ERH_0299nanH.1NeuraminidaseLPXTG
    ERH_0407cbpAUnknown, choline-binding proteinGW
    ERH_0561Glycosyl hydrolase, family 85LPXTG
    ERH_0668rspABiofilm formation, protective antigenLPXTG/KXW
    ERH_0669rspBBiofilm formationLPXTG/KXW
    ERH_0728Internalin-likeLPXTG
    ERH_0765hylBHyaluronidaseLPXTG
    ERH_0768cbpBUnknown, choline-binding proteinGW
    ERH_0777DipeptidaseLPXTG
    ERH_1139ushA5′-NucleotidaseLPXTG
    ERH_1210hylCHyaluronidaseLPXTG
    ERH_1258UnknownLPXTG
    ERH_1436Collagen-binding proteinLPXTG
    ERH_1454UnknownLPXTG
    ERH_1472Internalin-likeLPXTG
    ERH_1687rspCBiofilm formationLPXTG/KXW
Antioxidant proteins
    ERH_0162tpxThiol peroxidase
    ERH_0175ahpCAlkyl-hydroperoxide reductase
    ERH_0356nrdHGlutaredoxin
    ERH_0375trxA.1Thioredoxin
    ERH_1065sodASuperoxide dismutase
    ERH_1311trxB.1Thioredoxin-disulfide reductase
    ERH_1345ahpDAlkylhydroperoxide reductase
    ERH_1500trxA.2Thioredoxin
    ERH_1541trxB.2Thioredoxin-disulfide reductase
Phospholipase
    ERH_0072Patatin-like phospholipase
    ERH_0083Phospholipase/Carboxylesterase family
    ERH_0148pldBLysophospholipase
    ERH_0333clsCardiolipin synthetase
    ERH_0334Patatin-like phospholipase
    ERH_0347Phospholipase/carboxylesterase
    ERH_0388Phospholipase D
    ERH_1214Lysophospholipase
    ERH_1433Lysophospholipase
Hemolysins
    ERH_0467Hemolysin-related protein
    ERH_0649Hemolysin III
Other extracellular proteins/enzymes
    ERH_0761nanH.2Neuraminidase
    ERH_1034Fibronectin-binding protein
    ERH_1356Adhesin
    ERH_1467Biofilm formation
  • a LPXTG, sortase motif (33); GW, choline-binding module (59); KXW, module identified in extracellular matrix-binding proteins of Gram-positive bacteria (50).