TABLE 4.

Other known genes significantly dysregulated in psrA mutants, determined using a microarraya

Gene identifierbGene nameChange (fold)cP valueDescription
PA0106coxA−3.40.01Cytochrome c oxidase, subunit I
PA0217mdcR−4.80.007Transcriptional regulator
PA0459clpC−3.50.05ClpA/B protease ATP binding subunit
PA0507−3.20.001Probable acyl-CoA dehydrogenase
PA0511nirJ4.80.007Heme d1 biosynthesis protein
PA0512nirH2.30.04Conserved hypothetical protein
PA0513nirG4.50.008Probable transcriptional regulator
PA0517nirC−2.60.001c-type cytochrome
PA0530−4.30.04Pyridoxal phosphate-dependent aminotransferase
PA0588yeaG−3.30.001Conserved hypothetical protein
PA0707toxR−4.20.009ToxR/RegA transcriptional regulator
PA0719−4.10.009Bacteriophage Pf1 protein
PA0724coaA2.80.02Coat protein A of bacteriophage Pf1
PA0840−8.90.006Probable oxidoreductase
PA0852cbpD2.20.04Chitin-binding protein CbpD
PA1041−12.90.005OmpA-family outer membrane protein
PA1173napB−2.60.02Cytochrome c-type protein NapB
PA1187lcaD−2.10.04Acyl-CoA dehydrogenase
PA1399−2.00.004Probable LysR-family transcriptional regulator
PA1648−3.00.002Probable oxidoreductase
PA1649−6.30.0003Probable short-chain dehydrogenase
PA1650−2.00.008Probable transporter
PA1828−3.10.006Probable short-chain dehydrogenase
PA1881−2.20.03Probable oxidoreductase
PA1883−10.20.002NADH-ubiquinone/plastoquinone oxidoreductase
PA1927metE2.10.007Methionine synthase
PA1976−2.20.0009Two-component sensor kinase
PA1978agmR−2.90.003Two-component response regulator
PA1982exaA−2.70.03Quinoprotein ethanol dehydrogenase
PA1983exaB−2.70.02Cytochrome c550
PA1984exaC−3.60.05Aldehyde dehydrogenase
PA1985pqqA−4.50.002Pyrroloquinoline quinone biosynthesis protein A
PA21243.20.01Probable dehydrogenase
PA2277arsR0.05Transcriptional regulator
PA2278arsB0.02Ion transport membrane protein
PA2339mtlF−2.10.05Maltose/mannitol transport protein
PA23503.10.02Probable ATP-binding component of ABC transporter
PA23522.40.03Probable glycerophosphoryl diester phosphodiesterase
PA2371clpV3−3.00.02Probable ClpA/B-type protease
PA2396pvdF2.10.05Pyoverdine synthetase F
PA2398fpvA2.50.03Ferripyoverdine outer membrane receptor
PA24325.80.03Probable transcriptional regulator
PA2469−4.10.01Probable transcriptional regulator
PA2522czcC−3.70.01Outer membrane efflux protein
PA2535−2.30.05Probable oxidoreductase
PA2536ynbB2.20.03Phosphatidate cytidylyltransferase
PA2550−3.70.001Probable acyl-CoA dehydrogenase
PA2551−2.30.001Probable transcriptional regulator
PA2573−2.90.02Probable chemotaxis transducer
PA2664fhp−83.10.0004Flavohemoprotein
PA2892−2.20.04Probable short-chain dehydrogenase
PA2893−2.40.03Probable very-long-chain acyl-CoA synthetase
PA2939pepB−4.90.007Secreted aminopeptidase
PA30772.50.03Two-component response regulator
PA3145wbpL−2.50.03WbpL rhamnosyltransferase in LPS biosynthesis
PA3148wbpI−4.40.04UDP-N-acetylglucosamine 2-epimerase WbpI
PA3150wbpG−2.00.05LPS biosynthesis protein WbpG
PA3152hisH2−2.30.03Glutamine amidotransferase
PA3277−4.20.0003Probable short-chain dehydrogenase
PA3327−2.70.02Probable nonribosomal peptide synthetase
PA3387rhlG−2.70.0002Beta-ketoacyl reductase
PA3409−2.10.05Probable transmembrane sensor
PA3418ldh−3.0<0.0001Leucine dehydrogenase
PA3427−2.60.002Probable short-chain dehydrogenases
PA3454−2.10.002Probable acyl-CoA thiolase
PA36302.20.05Probable transcriptional regulator
PA3723yqiM−3.00.005FMN oxidoreductase
PA3877narK1−3.80.0008Nitrite extrusion protein 1
PA39573.70.01Probable short-chain dehydrogenase
PA4135−2.90.02Probable transcriptional regulator
PA4497−4.10.01Binding protein component of ABC transporter
PA4599mexC−2.00.008RND multidrug efflux membrane fusion protein
PA4654−5.60.02Major facilitator superfamily transporter
PA4911−6.60.004Probable permease of ABC amino acid transporter
PA5020−3.70.003Probable acyl-CoA dehydrogenase
PA5097hutT2.70.02Amino acid permease
PA5141hisA2.80.02Histidine biosynthesis protein
PA5187−3.20.0004Probable acyl-CoA dehydrogenase
PA5188−2.00.0004Probable 3-hydroxyacyl-CoA dehydrogenase
PA5234−2.20.005Probable oxidoreductase
PA5302dadX−3.30.02Catabolic alanine racemase
  • a Dysregulated hypothetical or unclassified open reading frames are not included. Only genes showing a ≥2-fold change in the psrA mutant are depicted.

  • b According to the P. aeruginosa genome website (http://www.pseudomonas.com/).

  • c Regulation of genes differentially expressed in the psrA mutant relative to the WT. A positive number indicates transcript upregulation in the psrA mutant.