TABLE 5.

Distribution of the new mutations among the sequenced genes in mutator and nonmutator isolates

Mutations or geneaMutator isolates (n = 15)Nonmutator isolates (n = 75)
No. of mutations (%)No. of mutations per isolateNo. of mutations (%)No. of mutations per isolate
All new mutations65 (100)4.3101 (100)1.3
All new mutations in antibiotic resistance genes23 (35.4)1.539 (38.6)0.52
mexZ (PA2020)9 (13.8)0.6020 (19.8)0.27
lasR (PA1430)8 (12.3)0.5314 (13.9)0.19
PA03138 (12.3)0.5312 (11.9)0.16
mexA (PA0425)4 (6.2)0.277 (6.9)0.09
accC (PA4848)3 (4.6)0.206 (5.9)0.08
vfr (PA0652)2 (3.1)0.135 (5.0)0.07
mexS (PA2491)1 (1.5)0.077 (6.9)0.09
exsA (PA1713)3 (4.6)0.206 (5.9)0.08
PA05062 (3.1)0.135 (5.0)0.07
wspF (PA3703)0 (<1.5)<0.074 (4.0)0.05
rpoN (PA4462)4 (6.2)0.273 (3.0)0.04
fleQ (PA1097)3 (4.6)0.202 (2.0)0.03
mexT (PA2492)4 (6.2)0.272 (2.0)0.03
  • a Only genes for which at least five mutated isolates were available are included. The two synonymous mutations detected (one from each group [mutators and nonmutators]) were excluded from the analysis.