TABLE 4.

Distribution of the types of new mutations in mutator and nonmutator isolates

Mutation typeNo. of new mutations (%)
Mutator isolates (n = 15)Nonmutator isolates (n = 75)
All new mutations66 (100)102 (100)
Base substitutions42 (63.6)69 (67.6)
Synonymous1 (1.5)1 (1.0)
Missense37 (56.1)52 (51.0)
Nonsense3 (4.5)11 (10.8)
Single-nucleotide polymorphisms (intergenic)1 (1.5)5 (4.9)
Insertions or deletions24 (36.4)33 (32.3)
    1- to 4-bp insertions or deletions14 (21.2)16 (15.7)
    >4-bp insertions or deletions10 (15.2)17 (16.7)