TABLE 1.

S. aureus mutants with reduced or enhanced pigmentation

Group, function, and strainPigmentationaGene name or description
Reduced pigmentation mutants
    crtOPQMN operon
        SAV2561 strain crtN
        SAV2562 strain crtM
        SAV2563 strain crtQ
        SAV2564 strain crtP
        SAV2565 strain crtO
    rsbUVW-sigB system
        SAV2064 strain sigB
        SAV2066 strain rsbV
        SAV2067 strain rsbU
    Other functions
        SAV1521 strain ispA
        SAV1524 strain nusB
Enhanced pigmentation mutants
    TCA cycle
        SAV1695 strain+++ citZ
        SAV1851 strain++ citG
        SAV2365 strain++Malate:quinine oxidoreductase
    Oxidative phosphorylation
        SAV1115 strain++ ctaA
        SAV1060 strain++ qoxB
    Purine biosynthesis
        SAV1072 strain+ purN
        SAV1073 strain+ purH
        SAV1074 strain+ purD
        SAV0017 strain+ purA
    Other functions
        SAV0672 strain+LysR family protein
        SAV1667 strain++ hemL
        SAV1108 strain++Hypothetical protein
        SAV1117 strain++Hypothetical protein
  • a −, reduced pigmentation observed on TSA plates compared to the wild-type Newman strain; +, enhanced pigmentation observed on TSA plates compared to the wild-type Newman strain. Additional plus signs indicate greater relative enhancement of pigmentation.