TABLE 3.

Polymorphic sites containing mutations unique to one lab strain or shared among a subset (excluding polymorphisms in PPE and PE_PGRS proteins)

Mutation type and positionaMutation in strainb:
H37RvCOH37RvAEH37RvMAH37RvHAH37RvLPH37RvJO
Mutations shared by all H37Rv variants but not found in H37Ra
    459399/NCc A → CA → CA → CA → CA → CA → C
Mutations shared by cluster 1
    Rv0050/ponA1 −CCG−CCG−CCG−CCG
    Rv0543cA81AA81AA81AA81A
    Rv0861c/ercc3 A410AA410AA410AA410A
    Rv1520Y200YY200YY200YY200Y
    Rv1771Q291RQ291RQ291RQ291R
    Rv1907cV158AV158AV158AV158A
Mutations shared by cluster 2
    Rv0179c/lprO L239LL239LL239L
    986204/NCC → AC → AC → A
    Rv2553cd +CAC(1)+CAC(1)+CAC(1)
    Rv2604cD151ED151ED151E
Mutations unique to H37RvAE
    Rv1063cR83R
    Rv1925/fadD31 H620N
    Rv2931/ppsA W1294*
Mutations shared by cluster 3
    Rv0480cR9HR9H
    Rv0538P402SP402S
    Rv0573cL275LL275L
    Rv2940c/mas e +GC+GC
    Rv3785−17 bp−17 bp
Mutations unique to H37RvLP
    Rv0282Y275H
    Rv0573cF252V
    Rv1949cG236G
    Rv2946c/pks1 D1463E
    Rv3645V393A
Mutations unique to H37RvJO
    Rv0282D138G
    1108537/NCf A → G
    Rv2542A348T
  • a NC, mutation is in a noncoding region.

  • b *, mutation to a stop codon.

  • c −84 bp upstream of Rv0383c; H37Ra has a −55 bp deletion here.

  • d In amino acid 53 out of 417 in Rv2553c (hypothetical protein).

  • e In amino acid 829 out of 2,111 in mas (mycocerosic acid synthase).

  • f −33 bp upstream of Rv0991c.