TABLE 1.

Results of cluster analysis

ClusterCategoryCommon name or characteristicLocus
AVirulenceTagD proteinVC0824
Toxin-coregulated pilus biosynthesis protein EVC0836
TCP pilus virulence regulatory proteinVC0838
Accessory colonization factor AcfBVC0840
TagE proteinVC0843
Accessory colonization factor AcfDVC0845
UnknownHypothetical proteinVC0712
Hypothetical proteinVC0821
Conserved hypothetical proteinVC0842
Hypothetical proteinVC1221
Conserved hypothetical proteinVC2278
Conserved hypothetical proteinVCA0006
Hypothetical proteinVCA0393
Hypothetical proteinVCA0394
Hypothetical proteinVCA0480
Hypothetical proteinVCA0817
Hypothetical proteinVCA0932
Transcription/translationDNA polymerase III, beta chainVC0013
Ribosomal protein L11VC0324
Ribosomal protein L10VC0326
Elongation factor GVC0361
Ribosomal protein L13VC0570
Elongation factor GVC2342
Ribosomal protein L36VC2575
Ribosomal protein L24VC2585
Ribosomal protein S3VC2590
Ribosomal protein L3VC2596
MetabolismCitrate lyase, gamma subunitVC0797
Cytochrome d ubiquinol oxidase, subunit IIVC1843
NADH:ubiquinone oxidoreductase, Na translocating, alpha subunitVC2295
UDP-N-acetylmuramate:l-alanyl-gamma-d-glutamyl-meso-diaminopimelate ligaseVC2542
Aspartate ammonia-lyaseVC2698
C4-dicarboxylate transporter, anaerobicVC2699
ATP synthase Fo, B subunitVC2768
ATP synthase Fo, A subunitVC2770
3,4-Dihydroxy-2-butanone 4-phosphate synthaseVCA1060
OtherLysE/YggA family proteinVC0481
Oligopeptide ABC transporter, permease proteinVC1092
Lipoprotein-releasing system permease proteinVC1882
Preprotein translocase, SecY subunitVC2576
Na+/H+ antiporter, putativeVCA0193
BVirulenceToxin-coregulated pilus biosynthesis protein QVC0830
Toxin-coregulated pilus biosynthesis outer membrane protein CVC0831
Toxin-coregulated pilus biosynthesis protein RVC0832
Accessory colonization factor AcfCVC0841
Cholera enterotoxin, B subunitVC1456
UnknownHypothetical proteinVC2098
Hypothetical proteinVCA0408
Hypothetical proteinVCA0619
Conserved hypothetical proteinVCA0689
Transcription/translationTranscription antitermination protein NusGVC0323
DNA-directed RNA polymerase, beta subunitVC0328
Ribosomal protein S7VC0360
Ribosomal protein L21VC0435
Cell division protein FtsHVC0637
Ribosomal protein L25VC1640
Ribosomal protein S11VC2573
Ribosomal protein L14VC2586
Ribosomal protein S17VC2587
Ribosomal protein S19VC2592
Ribosomal protein L31VC2679
MetabolismAldehyde dehydrogenaseVC0819
Long-chain-fatty acid transport proteinVC1043
Phosphoserine aminotransferaseVC1159
Glyceraldehyde 3-phosphate dehydrogenaseVC2000
EnolaseVC2447
OtherIron(III) compound receptorVC0200
NifR3/Smm1 family proteinVC0291
Antioxidant, AhpC/Tsa familyVC0731
Enterobactin synthetase component F-related proteinVC1579
Enterobactin receptor VctA, authentic frameshiftVCA0232
Arginine ABC transporter, periplasmic arginine-binding proteinVCA0759
DnaJ-related proteinVCA0788
CVirulenceToxin-coregulated pilus biosynthesis protein DVC0833
Toxin-coregulated pilus biosynthesis protein SVC0834
Toxin-coregulated pilus biosynthesis protein TVC0835
Leader peptidase TcpJVC0839
Accessory colonization factor AcfAVC0844
Transcription/translationRibosomal protein L19VC0564
DUnknownHypothetical proteinVC0507
Hypothetical proteinVCA0306
OtherRstB1 proteinVC1453
Chaperonin, 60-kDa subunitVC2664
C4-dicarboxylate transporter, anaerobicVCA0205
EUnknownConserved hypothetical proteinVC0340
Hypothetical proteinVC0546
Hypothetical proteinVC0569
Conserved hypothetical proteinVC0758
Conserved hypothetical proteinVC0770
Hypothetical proteinVC0967
Conserved hypothetical proteinVC1153
Conserved hypothetical proteinVC1354
Hypothetical proteinVC1794
Hypothetical proteinVC1924
Hypothetical proteinVC1999
Hypothetical proteinVC2149
Conserved hypothetical proteinVC2216
Hypothetical proteinVC2306
Hypothetical proteinVC2351
Conserved hypothetical proteinVC2523
Conserved hypothetical proteinVCA0835
Transcription/translationRNase P protein componentVC0006
Ribosomal protein L9VC0369
Alanyl-tRNA synthetaseVC0545
Peptidyl-tRNA hydrolaseVC2184
Elongation factor TsVC2259
Site-specific recombinase IntI4VCA0291
MetabolicPyrroline-5-carboxylate reductaseVC0460
Glutathione synthetaseVC0468
Hypoxanthine phosphoribosyltransferaseVC0585
Inositol monophosphate family proteinVC0745
Cytidine deaminaseVC1231
3-Hydroxydecanoyl-(acyl carrier protein) dehydrataseVC1483
Mannose-6-phosphate isomeraseVC1827
l-Asparaginase IVC1995
3-Oxoacyl-(acyl carrier protein) reductaseVC2021
Long-chain fatty acid-coenzyme A ligase, putativeVC2484
Periplasmic nitrate reductaseVCA0678
OtherATP-dependent DNA helicase RecQVC0196
Factor for inversion stimulation proteinVC0290
Cellobiose/cellodextrin-phosphorylase, putativeVC0612
Heat shock protein HslJVC1663
Heme exporter protein CVC2055
MinD-related proteinVC2067
Aerobic respiration control protein FexAVC2368
None (unclustered)VirulenceCholera enterotoxin, A subunitVC1457
UnknownHypothetical proteinVCA0435