TABLE 1.

Inhibitor constants for chenodeoxycholate and chenodeoxycholate analogs

CompoundKi a (μM)
CDCAb 378 ± 55
UCAb 213 ± 80
6KLAb 148 ± 60
LCAc 104 ± 12
3olAcc 123 ± 41
37D3AMEc 172 ± 96
37DAMEc 93 ± 32
37DMEc 44 ± 20
  • a Ki values were determined using the equation Ki = [inhibitor]/(Km taurocholate,obs/Km taurocholate − 1) and are listed as the averages from three independent experiments with one standard deviation of the means.

  • b Incubated with C. difficile spores at 2 mM.

  • c Incubated with C. difficile spores at 0.2 mM.